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Gastroduodenal inflammation in patients with non-ulcer dyspepsia. A controlled endoscopic and morphometric study.
Dig Dis Sci. 1985 Apr; 30(4):313-20.DD

Abstract

Proper control and quantitation are important in the accurate evaluation of gastroduodenal inflammation in dyspeptic patients without ulcers or erosions as proved by endoscopy. The endoscopic findings and the gastroduodenal mucosal inflammatory cell count in 31 patients with non-ulcer dyspepsia were compared with an age-matched group of 32 healthy controls. Endoscopy revealed similar mucosal changes and in similar frequency in both groups. Differential mucosal inflammatory cell count showed a statistically significant (P less than 0.001) increase in the neutrophil count in the gastric body, antrum, and duodenal cap of the dyspeptic group, as well as a slight but significant (P less than 0.05) increase in the round cell and eosinophil count of the duodenal mucosa alone. No correlation was found between the endoscopic changes and an increase in neutrophil count above a normal level determined by the healthy controls. However, an endoscopically normal mucosa was more likely to be associated with a normal neutrophil count. Active inflammation of the gastroduodenal mucosa likely accounts for the symptoms in patients with non-ulcer dyspepsia.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3979237

Citation

Toukan, A U., et al. "Gastroduodenal Inflammation in Patients With Non-ulcer Dyspepsia. a Controlled Endoscopic and Morphometric Study." Digestive Diseases and Sciences, vol. 30, no. 4, 1985, pp. 313-20.
Toukan AU, Kamal MF, Amr SS, et al. Gastroduodenal inflammation in patients with non-ulcer dyspepsia. A controlled endoscopic and morphometric study. Dig Dis Sci. 1985;30(4):313-20.
Toukan, A. U., Kamal, M. F., Amr, S. S., Arnaout, M. A., & Abu-Romiyeh, A. S. (1985). Gastroduodenal inflammation in patients with non-ulcer dyspepsia. A controlled endoscopic and morphometric study. Digestive Diseases and Sciences, 30(4), 313-20.
Toukan AU, et al. Gastroduodenal Inflammation in Patients With Non-ulcer Dyspepsia. a Controlled Endoscopic and Morphometric Study. Dig Dis Sci. 1985;30(4):313-20. PubMed PMID: 3979237.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastroduodenal inflammation in patients with non-ulcer dyspepsia. A controlled endoscopic and morphometric study. AU - Toukan,A U, AU - Kamal,M F, AU - Amr,S S, AU - Arnaout,M A, AU - Abu-Romiyeh,A S, PY - 1985/4/1/pubmed PY - 1985/4/1/medline PY - 1985/4/1/entrez SP - 313 EP - 20 JF - Digestive diseases and sciences JO - Dig Dis Sci VL - 30 IS - 4 N2 - Proper control and quantitation are important in the accurate evaluation of gastroduodenal inflammation in dyspeptic patients without ulcers or erosions as proved by endoscopy. The endoscopic findings and the gastroduodenal mucosal inflammatory cell count in 31 patients with non-ulcer dyspepsia were compared with an age-matched group of 32 healthy controls. Endoscopy revealed similar mucosal changes and in similar frequency in both groups. Differential mucosal inflammatory cell count showed a statistically significant (P less than 0.001) increase in the neutrophil count in the gastric body, antrum, and duodenal cap of the dyspeptic group, as well as a slight but significant (P less than 0.05) increase in the round cell and eosinophil count of the duodenal mucosa alone. No correlation was found between the endoscopic changes and an increase in neutrophil count above a normal level determined by the healthy controls. However, an endoscopically normal mucosa was more likely to be associated with a normal neutrophil count. Active inflammation of the gastroduodenal mucosa likely accounts for the symptoms in patients with non-ulcer dyspepsia. SN - 0163-2116 UR - https://www.unboundmedicine.com/medline/citation/3979237/Gastroduodenal_inflammation_in_patients_with_non_ulcer_dyspepsia__A_controlled_endoscopic_and_morphometric_study_ DB - PRIME DP - Unbound Medicine ER -