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Labetalol and pindolol in the treatment of hypertension: a comparative study.
Ann Clin Res. 1979 Dec; 11(6):249-52.AC

Abstract

Labetalol, a new hypotensive drug with both alpha- and beta-adrenoceptor antagonist properties, was compared with pindolol in a double blind cross-over study lasting 15 weeks. Both drugs caused a significant drop on blood pressure in both the standing and the supine position. The effect was seen after only two weeks treatment. The effect on the pulse rate was moderate. Three patients on pindolol (but none on labetalol) had to withdraw from the trial for medical reasons. In general the side effects recorded for labetalol and pindolol were mild. No postural hypotension was noticed with the moderate doses used in the study. Labetalol seems to be at least as effective as pindolol in mild to moderate hypertension.

Authors

Romo M
No affiliation info available
Halttunen P
No affiliation info available
Saarinen P
No affiliation info available
Sarna S
No affiliation info available

MeSH

AdultBlood PressureClinical Trials as TopicDouble-Blind MethodEthanolaminesFemaleHumansHypertensionLabetalolMaleMiddle AgedPindololPulse

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

398184

Citation

Romo, M, et al. "Labetalol and Pindolol in the Treatment of Hypertension: a Comparative Study." Annals of Clinical Research, vol. 11, no. 6, 1979, pp. 249-52.
Romo M, Halttunen P, Saarinen P, et al. Labetalol and pindolol in the treatment of hypertension: a comparative study. Ann Clin Res. 1979;11(6):249-52.
Romo, M., Halttunen, P., Saarinen, P., & Sarna, S. (1979). Labetalol and pindolol in the treatment of hypertension: a comparative study. Annals of Clinical Research, 11(6), 249-52.
Romo M, et al. Labetalol and Pindolol in the Treatment of Hypertension: a Comparative Study. Ann Clin Res. 1979;11(6):249-52. PubMed PMID: 398184.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Labetalol and pindolol in the treatment of hypertension: a comparative study. AU - Romo,M, AU - Halttunen,P, AU - Saarinen,P, AU - Sarna,S, PY - 1979/12/1/pubmed PY - 1979/12/1/medline PY - 1979/12/1/entrez SP - 249 EP - 52 JF - Annals of clinical research JO - Ann Clin Res VL - 11 IS - 6 N2 - Labetalol, a new hypotensive drug with both alpha- and beta-adrenoceptor antagonist properties, was compared with pindolol in a double blind cross-over study lasting 15 weeks. Both drugs caused a significant drop on blood pressure in both the standing and the supine position. The effect was seen after only two weeks treatment. The effect on the pulse rate was moderate. Three patients on pindolol (but none on labetalol) had to withdraw from the trial for medical reasons. In general the side effects recorded for labetalol and pindolol were mild. No postural hypotension was noticed with the moderate doses used in the study. Labetalol seems to be at least as effective as pindolol in mild to moderate hypertension. SN - 0003-4762 UR - https://www.unboundmedicine.com/medline/citation/398184/Labetalol_and_pindolol_in_the_treatment_of_hypertension:_a_comparative_study_ DB - PRIME DP - Unbound Medicine ER -