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Reproductive and hormonal factors and breast cancer in a Northern Italian population.

Abstract

Between January 1980 and March 1983, data were collected to evaluate risk factors for breast cancer in a case-control study based on 368 women with breast cancer admitted to the General Hospital of Pordenone (a district in North Eastern Italy with a particularly high breast cancer mortality rate), and 373 age-matched controls. Nulliparity or low parity, late age at first birth and later menopause were associated with an increased risk of breast cancer. The elevated risk associated with nulliparity could be almost completely explained by marital status, thus pointing to a specific protection given by parity, rather than some putative influence of infertility or subfertility in breast cancer cases. Likewise, risk did not vary materially according to history of abortions when marital status was controlled for. Increased risk associated with later age at first birth, on the other hand, was not accounted for by marital status or parity. The population studied, though frequently multiparous, showed late average at first birth: this might, at least partly, explain its high mortality rate from breast cancer. The risk estimate was higher if menarche occurred below age 15; however, there was no evidence of a trend for the relative risk to rise with lower age at menarche. The use of oral contraceptives or other female hormones (such as oestrogen replacement therapy) did not appear to be related to the risk of breast cancer. The role of the major menstrual and reproductive variables considered (age at menarche, parity, age at first birth) was apparently stronger in pre-menopausal women, thus suggesting an influence of these factors (and possibly, their hormonal correlates) on one of the latter stages of the process of carcinogenesis.

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  • Authors

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    MeSH

    Abortion, Spontaneous
    Adult
    Breast Neoplasms
    Contraceptives, Oral
    Female
    Humans
    Italy
    Marriage
    Maternal Age
    Menarche
    Menopause
    Middle Aged
    Parity
    Pregnancy
    Risk

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    3988443

    Citation

    Talamini, R, et al. "Reproductive and Hormonal Factors and Breast Cancer in a Northern Italian Population." International Journal of Epidemiology, vol. 14, no. 1, 1985, pp. 70-4.
    Talamini R, La Vecchia C, Franceschi S, et al. Reproductive and hormonal factors and breast cancer in a Northern Italian population. Int J Epidemiol. 1985;14(1):70-4.
    Talamini, R., La Vecchia, C., Franceschi, S., Colombo, F., Decarli, A., Grattoni, E., ... Tognoni, G. (1985). Reproductive and hormonal factors and breast cancer in a Northern Italian population. International Journal of Epidemiology, 14(1), pp. 70-4.
    Talamini R, et al. Reproductive and Hormonal Factors and Breast Cancer in a Northern Italian Population. Int J Epidemiol. 1985;14(1):70-4. PubMed PMID: 3988443.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Reproductive and hormonal factors and breast cancer in a Northern Italian population. AU - Talamini,R, AU - La Vecchia,C, AU - Franceschi,S, AU - Colombo,F, AU - Decarli,A, AU - Grattoni,E, AU - Grigoletto,E, AU - Tognoni,G, PY - 1985/3/1/pubmed PY - 1985/3/1/medline PY - 1985/3/1/entrez KW - Age Factors KW - Breast Cancer KW - Cancer KW - Comparative Studies KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Female KW - Contraceptive Methods--side effects KW - Contraceptive Usage KW - Demographic Factors KW - Developed Countries KW - Diseases KW - Estrogens KW - Europe KW - Family Planning KW - Fertility KW - Fertility Measurements KW - Hormones KW - Italy KW - Marital Status KW - Measurement KW - Mediterranean Countries KW - Menarche KW - Menopause KW - Menstruation KW - Mortality KW - Neoplasms KW - Nuptiality KW - Oral Contraceptives--side effects KW - Parity KW - Population KW - Population Characteristics KW - Population Dynamics KW - Reproduction KW - Reproductive Behavior KW - Reproductive Control Agents KW - Research Methodology KW - Sampling Studies KW - Southern Europe KW - Studies KW - Surveys SP - 70 EP - 4 JF - International journal of epidemiology JO - Int J Epidemiol VL - 14 IS - 1 N2 - Between January 1980 and March 1983, data were collected to evaluate risk factors for breast cancer in a case-control study based on 368 women with breast cancer admitted to the General Hospital of Pordenone (a district in North Eastern Italy with a particularly high breast cancer mortality rate), and 373 age-matched controls. Nulliparity or low parity, late age at first birth and later menopause were associated with an increased risk of breast cancer. The elevated risk associated with nulliparity could be almost completely explained by marital status, thus pointing to a specific protection given by parity, rather than some putative influence of infertility or subfertility in breast cancer cases. Likewise, risk did not vary materially according to history of abortions when marital status was controlled for. Increased risk associated with later age at first birth, on the other hand, was not accounted for by marital status or parity. The population studied, though frequently multiparous, showed late average at first birth: this might, at least partly, explain its high mortality rate from breast cancer. The risk estimate was higher if menarche occurred below age 15; however, there was no evidence of a trend for the relative risk to rise with lower age at menarche. The use of oral contraceptives or other female hormones (such as oestrogen replacement therapy) did not appear to be related to the risk of breast cancer. The role of the major menstrual and reproductive variables considered (age at menarche, parity, age at first birth) was apparently stronger in pre-menopausal women, thus suggesting an influence of these factors (and possibly, their hormonal correlates) on one of the latter stages of the process of carcinogenesis. SN - 0300-5771 UR - https://www.unboundmedicine.com/medline/citation/3988443/Reproductive_and_hormonal_factors_and_breast_cancer_in_a_Northern_Italian_population_ L2 - https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/14.1.70 DB - PRIME DP - Unbound Medicine ER -