Tags

Type your tag names separated by a space and hit enter

Reduction of plasma lipids, lipoproteins, and apoproteins by dietary fish oils in patients with hypertriglyceridemia.
N Engl J Med 1985; 312(19):1210-6NEJM

Abstract

Dietary fish oils, which are rich in omega-3 fatty acids, have been reported to reduce plasma lipid levels in normolipidemic subjects. We examined the effects of fish oil in 20 hypertriglyceridemic patients: 10 with Type IIb hyperlipidemia and 10 with Type V. These patients were put on three diets differing primarily in fatty acid composition and fat content. The control diet contained a fatty acid mixture typical of a low-fat therapeutic diet (ratio of polyunsaturated to saturated fat, 1.4), the fish-oil diet contained omega-3 fatty acids, and the vegetable-oil diet was rich in the omega-6 fatty acid, linoleic acid. Each diet was followed for four weeks. In the Type IIb group, the fish-oil diet led to decreases in both plasma cholesterol (-27 per cent) and triglyceride (-64 per cent), as compared with the control diet. Very-low-density lipoproteins (VLDLs) were also reduced markedly. The vegetable-oil diet had much less effect. With fish oil, the Type V group had marked decreases in total cholesterol and triglyceride levels (-45 and -79 per cent, respectively). VLDL levels were dramatically lowered, as were apoprotein E levels. The vegetable-oil diet (unlike the fish-oil diet) produced a rapid and significant rise in plasma triglyceride levels. We conclude that fish oils and fish may be useful components of diets for the treatment of hypertriglyceridemia.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3990714

Citation

Phillipson, B E., et al. "Reduction of Plasma Lipids, Lipoproteins, and Apoproteins By Dietary Fish Oils in Patients With Hypertriglyceridemia." The New England Journal of Medicine, vol. 312, no. 19, 1985, pp. 1210-6.
Phillipson BE, Rothrock DW, Connor WE, et al. Reduction of plasma lipids, lipoproteins, and apoproteins by dietary fish oils in patients with hypertriglyceridemia. N Engl J Med. 1985;312(19):1210-6.
Phillipson, B. E., Rothrock, D. W., Connor, W. E., Harris, W. S., & Illingworth, D. R. (1985). Reduction of plasma lipids, lipoproteins, and apoproteins by dietary fish oils in patients with hypertriglyceridemia. The New England Journal of Medicine, 312(19), pp. 1210-6.
Phillipson BE, et al. Reduction of Plasma Lipids, Lipoproteins, and Apoproteins By Dietary Fish Oils in Patients With Hypertriglyceridemia. N Engl J Med. 1985 May 9;312(19):1210-6. PubMed PMID: 3990714.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduction of plasma lipids, lipoproteins, and apoproteins by dietary fish oils in patients with hypertriglyceridemia. AU - Phillipson,B E, AU - Rothrock,D W, AU - Connor,W E, AU - Harris,W S, AU - Illingworth,D R, PY - 1985/5/9/pubmed PY - 1985/5/9/medline PY - 1985/5/9/entrez SP - 1210 EP - 6 JF - The New England journal of medicine JO - N. Engl. J. Med. VL - 312 IS - 19 N2 - Dietary fish oils, which are rich in omega-3 fatty acids, have been reported to reduce plasma lipid levels in normolipidemic subjects. We examined the effects of fish oil in 20 hypertriglyceridemic patients: 10 with Type IIb hyperlipidemia and 10 with Type V. These patients were put on three diets differing primarily in fatty acid composition and fat content. The control diet contained a fatty acid mixture typical of a low-fat therapeutic diet (ratio of polyunsaturated to saturated fat, 1.4), the fish-oil diet contained omega-3 fatty acids, and the vegetable-oil diet was rich in the omega-6 fatty acid, linoleic acid. Each diet was followed for four weeks. In the Type IIb group, the fish-oil diet led to decreases in both plasma cholesterol (-27 per cent) and triglyceride (-64 per cent), as compared with the control diet. Very-low-density lipoproteins (VLDLs) were also reduced markedly. The vegetable-oil diet had much less effect. With fish oil, the Type V group had marked decreases in total cholesterol and triglyceride levels (-45 and -79 per cent, respectively). VLDL levels were dramatically lowered, as were apoprotein E levels. The vegetable-oil diet (unlike the fish-oil diet) produced a rapid and significant rise in plasma triglyceride levels. We conclude that fish oils and fish may be useful components of diets for the treatment of hypertriglyceridemia. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/3990714/Reduction_of_plasma_lipids_lipoproteins_and_apoproteins_by_dietary_fish_oils_in_patients_with_hypertriglyceridemia_ L2 - http://www.nejm.org/doi/full/10.1056/NEJM198505093121902?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -