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Red cell distribution width parallels dense red cell disappearance during painful crises in sickle cell anemia.

Abstract

We reported previously that painful crises in patients with sickle cell anemia are accompanied by striking decreases in the percent of densest red cells (fraction 4) when studied with isopyknic Percoll-Stractan gradients. We report that an alternative to density gradients is the red cell distribution width (RDW), an estimate of red cell size variation measured with a Coulter counter. In 17 painful crises in 12 patients with homozygous sickle cell anemia the RDWs decreased in each crisis, from an initial mean of 16.2 +/- 1.8 SD to 12.8 +/- 1.3 (P less than 0.001). In patients in whom serial measurements of both RDW and fraction 4 (very dense) red cells were taken during crisis, the two measurements declined in parallel. The decrease of RDW is a readily observable and objective laboratory concomitant of painful sickle crisis.

Authors

, ,

Source

MeSH

Anemia, Sickle Cell
Blood Sedimentation
Centrifugation, Isopycnic
Erythrocyte Count
Erythrocyte Indices
Erythrocytes, Abnormal
Humans

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3998622

Citation

Lawrence, C, et al. "Red Cell Distribution Width Parallels Dense Red Cell Disappearance During Painful Crises in Sickle Cell Anemia." The Journal of Laboratory and Clinical Medicine, vol. 105, no. 6, 1985, pp. 706-10.
Lawrence C, Fabry ME, Nagel RL. Red cell distribution width parallels dense red cell disappearance during painful crises in sickle cell anemia. J Lab Clin Med. 1985;105(6):706-10.
Lawrence, C., Fabry, M. E., & Nagel, R. L. (1985). Red cell distribution width parallels dense red cell disappearance during painful crises in sickle cell anemia. The Journal of Laboratory and Clinical Medicine, 105(6), pp. 706-10.
Lawrence C, Fabry ME, Nagel RL. Red Cell Distribution Width Parallels Dense Red Cell Disappearance During Painful Crises in Sickle Cell Anemia. J Lab Clin Med. 1985;105(6):706-10. PubMed PMID: 3998622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Red cell distribution width parallels dense red cell disappearance during painful crises in sickle cell anemia. AU - Lawrence,C, AU - Fabry,M E, AU - Nagel,R L, PY - 1985/6/1/pubmed PY - 1985/6/1/medline PY - 1985/6/1/entrez SP - 706 EP - 10 JF - The Journal of laboratory and clinical medicine JO - J. Lab. Clin. Med. VL - 105 IS - 6 N2 - We reported previously that painful crises in patients with sickle cell anemia are accompanied by striking decreases in the percent of densest red cells (fraction 4) when studied with isopyknic Percoll-Stractan gradients. We report that an alternative to density gradients is the red cell distribution width (RDW), an estimate of red cell size variation measured with a Coulter counter. In 17 painful crises in 12 patients with homozygous sickle cell anemia the RDWs decreased in each crisis, from an initial mean of 16.2 +/- 1.8 SD to 12.8 +/- 1.3 (P less than 0.001). In patients in whom serial measurements of both RDW and fraction 4 (very dense) red cells were taken during crisis, the two measurements declined in parallel. The decrease of RDW is a readily observable and objective laboratory concomitant of painful sickle crisis. SN - 0022-2143 UR - https://www.unboundmedicine.com/medline/citation/3998622/Red_cell_distribution_width_parallels_dense_red_cell_disappearance_during_painful_crises_in_sickle_cell_anemia_ L2 - http://www.diseaseinfosearch.org/result/441 DB - PRIME DP - Unbound Medicine ER -