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Leukotriene inhibition prevents and reverses hypoxic pulmonary vasoconstriction in newborn lambs.
Pediatr Res. 1985 May; 19(5):437-41.PR

Abstract

The effects of the leukotriene antagonist FPL 57231 on the circulation were studied in spontaneously breathing normoxic and hypoxic newborn lambs in order to evaluate the role of leukotrienes in the perinatal control of hypoxic pulmonary vasoconstriction. Hypoxia produced a 58% increase in pulmonary arterial pressure (p less than 0.05) and a 37% increase in pulmonary vascular resistance (p less than 0.05). Hypoxic pulmonary vasoconstriction was abolished by the prior infusion of FPL 57231. Pulmonary arterial pressure increased by only 8% and pulmonary vascular resistance decreased by 10% from normoxia. The infusion of FPL 57231 during hypoxia-induced pulmonary vasoconstriction reversed the increase in pulmonary arterial pressure (p less than 0.05) and pulmonary vascular resistance (p less than 0.05). The hypoxia-induced increase in cardiac output was maintained during the infusion of FPL 57231. Leukotrienes may play a significant role in the mediation of hypoxic pulmonary vasoconstriction. Leukotriene inhibition with FPL 57231 may be useful in the management of infants with persistent pulmonary hypertension syndrome.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

4000769

Citation

Schreiber, M D., et al. "Leukotriene Inhibition Prevents and Reverses Hypoxic Pulmonary Vasoconstriction in Newborn Lambs." Pediatric Research, vol. 19, no. 5, 1985, pp. 437-41.
Schreiber MD, Heymann MA, Soifer SJ. Leukotriene inhibition prevents and reverses hypoxic pulmonary vasoconstriction in newborn lambs. Pediatr Res. 1985;19(5):437-41.
Schreiber, M. D., Heymann, M. A., & Soifer, S. J. (1985). Leukotriene inhibition prevents and reverses hypoxic pulmonary vasoconstriction in newborn lambs. Pediatric Research, 19(5), 437-41.
Schreiber MD, Heymann MA, Soifer SJ. Leukotriene Inhibition Prevents and Reverses Hypoxic Pulmonary Vasoconstriction in Newborn Lambs. Pediatr Res. 1985;19(5):437-41. PubMed PMID: 4000769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leukotriene inhibition prevents and reverses hypoxic pulmonary vasoconstriction in newborn lambs. AU - Schreiber,M D, AU - Heymann,M A, AU - Soifer,S J, PY - 1985/5/1/pubmed PY - 1985/5/1/medline PY - 1985/5/1/entrez SP - 437 EP - 41 JF - Pediatric research JO - Pediatr Res VL - 19 IS - 5 N2 - The effects of the leukotriene antagonist FPL 57231 on the circulation were studied in spontaneously breathing normoxic and hypoxic newborn lambs in order to evaluate the role of leukotrienes in the perinatal control of hypoxic pulmonary vasoconstriction. Hypoxia produced a 58% increase in pulmonary arterial pressure (p less than 0.05) and a 37% increase in pulmonary vascular resistance (p less than 0.05). Hypoxic pulmonary vasoconstriction was abolished by the prior infusion of FPL 57231. Pulmonary arterial pressure increased by only 8% and pulmonary vascular resistance decreased by 10% from normoxia. The infusion of FPL 57231 during hypoxia-induced pulmonary vasoconstriction reversed the increase in pulmonary arterial pressure (p less than 0.05) and pulmonary vascular resistance (p less than 0.05). The hypoxia-induced increase in cardiac output was maintained during the infusion of FPL 57231. Leukotrienes may play a significant role in the mediation of hypoxic pulmonary vasoconstriction. Leukotriene inhibition with FPL 57231 may be useful in the management of infants with persistent pulmonary hypertension syndrome. SN - 0031-3998 UR - https://www.unboundmedicine.com/medline/citation/4000769/Leukotriene_inhibition_prevents_and_reverses_hypoxic_pulmonary_vasoconstriction_in_newborn_lambs_ L2 - https://doi.org/10.1203/00006450-198505000-00006 DB - PRIME DP - Unbound Medicine ER -