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The effects of hydrogenated coconut oil, safflower oil, and evening primrose oil on development of hypertension and sodium handling in spontaneously hypertensive rats.
Can J Physiol Pharmacol. 1985 Apr; 63(4):325-30.CJ

Abstract

Spontaneously hypertensive rats (SHR) were fed a basal regular diet (BD) or three different fat-supplemented diets which contained 10% hydrogenated coconut oil (HCO), 10% safflower oil (SFO), or 10% evening primrose oil (EPO). The rats received these four different diets from 4 weeks to over 24 weeks of age. The development of hypertension in SHR was significantly retarded in the EPO-supplemented animals. The blood pressure was lower in the SFO group animals as compared with the BD and HCO groups, but this did not reach significance. Sodium excretion rate in young SHR was increased in the EPO group compared with the HCO and SFO groups, and the urinary K/Na ratio was decreased in the EPO group compared with the HCO and EPO groups. Water intake and urine volume were increased in the SFO group as compared with the HCO and EPO groups. Sodium concentration in erythrocytes was decreased in the rats receiving SFO. Pressor responses to norepinephrine and angiotensin II were enhanced in the EPO and SFO groups as compared with the basal chow group. These data suggest that a dietary supplementation of EPO which contains a substantial amount of gamma-linolenic acid consistently lowers blood pressure in SHR. The mechanism is uncertain, but the effects on sodium handling may in part be responsible for the retardation of the development of hypertension. There was a difference between the EPO and the SFO groups in sodium--water handling, and to some extent in the blood pressure development in SHR.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

4005704

Citation

Soma, M, et al. "The Effects of Hydrogenated Coconut Oil, Safflower Oil, and Evening Primrose Oil On Development of Hypertension and Sodium Handling in Spontaneously Hypertensive Rats." Canadian Journal of Physiology and Pharmacology, vol. 63, no. 4, 1985, pp. 325-30.
Soma M, Manku MS, Horrobin DF. The effects of hydrogenated coconut oil, safflower oil, and evening primrose oil on development of hypertension and sodium handling in spontaneously hypertensive rats. Can J Physiol Pharmacol. 1985;63(4):325-30.
Soma, M., Manku, M. S., & Horrobin, D. F. (1985). The effects of hydrogenated coconut oil, safflower oil, and evening primrose oil on development of hypertension and sodium handling in spontaneously hypertensive rats. Canadian Journal of Physiology and Pharmacology, 63(4), 325-30.
Soma M, Manku MS, Horrobin DF. The Effects of Hydrogenated Coconut Oil, Safflower Oil, and Evening Primrose Oil On Development of Hypertension and Sodium Handling in Spontaneously Hypertensive Rats. Can J Physiol Pharmacol. 1985;63(4):325-30. PubMed PMID: 4005704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of hydrogenated coconut oil, safflower oil, and evening primrose oil on development of hypertension and sodium handling in spontaneously hypertensive rats. AU - Soma,M, AU - Manku,M S, AU - Horrobin,D F, PY - 1985/4/1/pubmed PY - 1985/4/1/medline PY - 1985/4/1/entrez SP - 325 EP - 30 JF - Canadian journal of physiology and pharmacology JO - Can J Physiol Pharmacol VL - 63 IS - 4 N2 - Spontaneously hypertensive rats (SHR) were fed a basal regular diet (BD) or three different fat-supplemented diets which contained 10% hydrogenated coconut oil (HCO), 10% safflower oil (SFO), or 10% evening primrose oil (EPO). The rats received these four different diets from 4 weeks to over 24 weeks of age. The development of hypertension in SHR was significantly retarded in the EPO-supplemented animals. The blood pressure was lower in the SFO group animals as compared with the BD and HCO groups, but this did not reach significance. Sodium excretion rate in young SHR was increased in the EPO group compared with the HCO and SFO groups, and the urinary K/Na ratio was decreased in the EPO group compared with the HCO and EPO groups. Water intake and urine volume were increased in the SFO group as compared with the HCO and EPO groups. Sodium concentration in erythrocytes was decreased in the rats receiving SFO. Pressor responses to norepinephrine and angiotensin II were enhanced in the EPO and SFO groups as compared with the basal chow group. These data suggest that a dietary supplementation of EPO which contains a substantial amount of gamma-linolenic acid consistently lowers blood pressure in SHR. The mechanism is uncertain, but the effects on sodium handling may in part be responsible for the retardation of the development of hypertension. There was a difference between the EPO and the SFO groups in sodium--water handling, and to some extent in the blood pressure development in SHR. SN - 0008-4212 UR - https://www.unboundmedicine.com/medline/citation/4005704/The_effects_of_hydrogenated_coconut_oil_safflower_oil_and_evening_primrose_oil_on_development_of_hypertension_and_sodium_handling_in_spontaneously_hypertensive_rats_ L2 - https://cdnsciencepub.com/doi/10.1139/y85-059?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -