Tags

Type your tag names separated by a space and hit enter

Hyperprolactinemia and hypogonadism in the human female.
Eur J Obstet Gynecol Reprod Biol. 1977; 7(5):337-48.EJ

Abstract

Prolactin is a mammotropic hormone essential for the initiation of lactation. It also influences ovarian function; during hyperprolactinemia hypogonadism occurs. This is true for pathological forms of hyperprolactinemia but also for the early puerperium when there is physiological hyperprolactinemia. Amenorrhea is a better parameter of hyperprolactinemia than galactorrhea. The mechanisms by which prolactin disrupts ovarian function are not as yet fully understood; it probably alters hypothalamic neurotransmitter content through a direct feedback mechanism resulting in a decrease of Gn-RH. However, the direct effect of prolactin-producing pituitary tumors on the capacity of the gonadotrophs or a direct interference of prolactin at the gonadal level are also possibilities. Hyperprolactinemia can be treated very effectively with bromocriptine and this drug appears to have become the favorite form of treatment. In the case of obvious tumors hypophysectomy is indicated. When there are smaller tumors irradiation of the pituitary gland previous to bromocriptine treatment may prevent expansion of the gland during subsequent pregnancy.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

400856

Citation

Rolland, R, and R S. Corbey. "Hyperprolactinemia and Hypogonadism in the Human Female." European Journal of Obstetrics, Gynecology, and Reproductive Biology, vol. 7, no. 5, 1977, pp. 337-48.
Rolland R, Corbey RS. Hyperprolactinemia and hypogonadism in the human female. Eur J Obstet Gynecol Reprod Biol. 1977;7(5):337-48.
Rolland, R., & Corbey, R. S. (1977). Hyperprolactinemia and hypogonadism in the human female. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 7(5), 337-48.
Rolland R, Corbey RS. Hyperprolactinemia and Hypogonadism in the Human Female. Eur J Obstet Gynecol Reprod Biol. 1977;7(5):337-48. PubMed PMID: 400856.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperprolactinemia and hypogonadism in the human female. AU - Rolland,R, AU - Corbey,R S, PY - 1977/1/1/pubmed PY - 1977/1/1/medline PY - 1977/1/1/entrez KW - Alkaloids KW - Amenorrhea KW - Biology KW - Diseases KW - Endocrine System KW - Ergot Alkaloids--therapeutic use KW - Feedback KW - Follicle Stimulating Hormone KW - Galactorrhea KW - Genitalia KW - Genitalia, Female KW - Hormones KW - Ingredients And Chemicals KW - Lactation KW - Literature Review KW - Luteinizing Hormone KW - Menstruation Disorders KW - Organic Chemicals KW - Ovarian Effects KW - Ovary KW - Physiology KW - Pituitary Hormone Releasing Hormones KW - Pituitary Hormones KW - Pregnancy, Second Trimester KW - Pregnancy, Third Trimester KW - Prolactin--side effects KW - Reproduction KW - Urogenital System SP - 337 EP - 48 JF - European journal of obstetrics, gynecology, and reproductive biology JO - Eur J Obstet Gynecol Reprod Biol VL - 7 IS - 5 N2 - Prolactin is a mammotropic hormone essential for the initiation of lactation. It also influences ovarian function; during hyperprolactinemia hypogonadism occurs. This is true for pathological forms of hyperprolactinemia but also for the early puerperium when there is physiological hyperprolactinemia. Amenorrhea is a better parameter of hyperprolactinemia than galactorrhea. The mechanisms by which prolactin disrupts ovarian function are not as yet fully understood; it probably alters hypothalamic neurotransmitter content through a direct feedback mechanism resulting in a decrease of Gn-RH. However, the direct effect of prolactin-producing pituitary tumors on the capacity of the gonadotrophs or a direct interference of prolactin at the gonadal level are also possibilities. Hyperprolactinemia can be treated very effectively with bromocriptine and this drug appears to have become the favorite form of treatment. In the case of obvious tumors hypophysectomy is indicated. When there are smaller tumors irradiation of the pituitary gland previous to bromocriptine treatment may prevent expansion of the gland during subsequent pregnancy. SN - 0301-2115 UR - https://www.unboundmedicine.com/medline/citation/400856/Hyperprolactinemia_and_hypogonadism_in_the_human_female_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0028-2243(77)90019-3 DB - PRIME DP - Unbound Medicine ER -