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The effect of Alcide, a new antimicrobial drug, on rat blood glutathione and erythrocyte osmotic fragility, in vitro.
J Appl Toxicol. 1985 Jun; 5(3):178-81.JA

Abstract

Alcide is an antimicrobial drug which has been demonstrated to kill a variety of common pathogenic bacteria as well as fungi, in vitro. This agent is supplied in liquid and gel forms and consists of two parts, one of which contains sodium chlorite, while the other contains lactic acid as the active ingredients. Mixing of the two parts prior to use produces chlorine dioxide (ClO2), a strong oxidizing agent. A dose-dependent decrease in glutathione content and erythrocyte osmotic fragility occurred after incubation of whole blood with Alcide. Glutathione concentration and erythrocyte osmotic fragility approached the control values after 240 min of incubation with Alcide containing 1 mM NaClO2. The addition of exogenous glutathione (50 mg 100 ml-1) or glutathione reductase and NADPH to rat blood in the presence of Alcide returned erythrocyte osmotic fragility to control values. Treatment of rat blood with Alcide did not change glutathione reductase or glutathione peroxidase activities after 1 h of incubation.

Authors

Abdel-Rahman MS
No affiliation info available
Scatina J
No affiliation info available

MeSH

AnimalsChlorineChlorine CompoundsDisinfectantsGlutathioneGlutathione PeroxidaseGlutathione ReductaseIn Vitro TechniquesMaleNADPOsmotic FragilityOxidesRatsRats, Inbred StrainsTime Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

4008865

Citation

Abdel-Rahman, M S., and J Scatina. "The Effect of Alcide, a New Antimicrobial Drug, On Rat Blood Glutathione and Erythrocyte Osmotic Fragility, in Vitro." Journal of Applied Toxicology : JAT, vol. 5, no. 3, 1985, pp. 178-81.
Abdel-Rahman MS, Scatina J. The effect of Alcide, a new antimicrobial drug, on rat blood glutathione and erythrocyte osmotic fragility, in vitro. J Appl Toxicol. 1985;5(3):178-81.
Abdel-Rahman, M. S., & Scatina, J. (1985). The effect of Alcide, a new antimicrobial drug, on rat blood glutathione and erythrocyte osmotic fragility, in vitro. Journal of Applied Toxicology : JAT, 5(3), 178-81.
Abdel-Rahman MS, Scatina J. The Effect of Alcide, a New Antimicrobial Drug, On Rat Blood Glutathione and Erythrocyte Osmotic Fragility, in Vitro. J Appl Toxicol. 1985;5(3):178-81. PubMed PMID: 4008865.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of Alcide, a new antimicrobial drug, on rat blood glutathione and erythrocyte osmotic fragility, in vitro. AU - Abdel-Rahman,M S, AU - Scatina,J, PY - 1985/6/1/pubmed PY - 1985/6/1/medline PY - 1985/6/1/entrez SP - 178 EP - 81 JF - Journal of applied toxicology : JAT JO - J Appl Toxicol VL - 5 IS - 3 N2 - Alcide is an antimicrobial drug which has been demonstrated to kill a variety of common pathogenic bacteria as well as fungi, in vitro. This agent is supplied in liquid and gel forms and consists of two parts, one of which contains sodium chlorite, while the other contains lactic acid as the active ingredients. Mixing of the two parts prior to use produces chlorine dioxide (ClO2), a strong oxidizing agent. A dose-dependent decrease in glutathione content and erythrocyte osmotic fragility occurred after incubation of whole blood with Alcide. Glutathione concentration and erythrocyte osmotic fragility approached the control values after 240 min of incubation with Alcide containing 1 mM NaClO2. The addition of exogenous glutathione (50 mg 100 ml-1) or glutathione reductase and NADPH to rat blood in the presence of Alcide returned erythrocyte osmotic fragility to control values. Treatment of rat blood with Alcide did not change glutathione reductase or glutathione peroxidase activities after 1 h of incubation. SN - 0260-437X UR - https://www.unboundmedicine.com/medline/citation/4008865/The_effect_of_Alcide_a_new_antimicrobial_drug_on_rat_blood_glutathione_and_erythrocyte_osmotic_fragility_in_vitro_ DB - PRIME DP - Unbound Medicine ER -