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Effects of the degree of saturation of dietary fat on the hepatic production of lipoproteins in the African green monkey.
J Lipid Res. 1985 Apr; 26(4):403-17.JL

Abstract

The cholesteryl ester content of plasma low density lipoproteins (LDL) in monkeys has previously been shown to be related to the rate of hepatic cholesterol secretion and cholesteryl ester content of newly secreted lipoproteins in the isolated perfused liver. In the present studies, African green monkeys were fed diets containing cholesterol and 40% of calories as either butter or safflower oil in order to determine the effects of saturated versus polyunsaturated dietary fat on hepatic lipoprotein secretion. The rate of cholesterol accumulation in liver perfusates was correlated with the size of the donor's plasma LDL, but for any rate, a smaller plasma LDL was found in donor animals of the safflower oil group than in those of the butter group. Hepatic very low density lipoproteins (VLDL) were smaller in the safflower oil group but contained more cholesteryl ester and fewer triglyceride molecules per particle than those from the butter group. Livers from the safflower oil group contained more cholesteryl ester and less triglyceride than those from the butter group. The cholesteryl ester percentage composition of hepatic VLDL resembled that of the liver in each group. The data show that dietary polyunsaturated fat decreased plasma LDL size even though it increased the cholesteryl ester content of lipoproteins secreted by the liver. Therefore, intravascular formation of plasma LDL from hepatic precursor lipoproteins appears to include the removal of relatively greater amounts of cholesteryl esters from the precursor lipoproteins in polyunsaturated fat-fed animals.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

4009059

Citation

Johnson, F L., et al. "Effects of the Degree of Saturation of Dietary Fat On the Hepatic Production of Lipoproteins in the African Green Monkey." Journal of Lipid Research, vol. 26, no. 4, 1985, pp. 403-17.
Johnson FL, St Clair RW, Rudel LL. Effects of the degree of saturation of dietary fat on the hepatic production of lipoproteins in the African green monkey. J Lipid Res. 1985;26(4):403-17.
Johnson, F. L., St Clair, R. W., & Rudel, L. L. (1985). Effects of the degree of saturation of dietary fat on the hepatic production of lipoproteins in the African green monkey. Journal of Lipid Research, 26(4), 403-17.
Johnson FL, St Clair RW, Rudel LL. Effects of the Degree of Saturation of Dietary Fat On the Hepatic Production of Lipoproteins in the African Green Monkey. J Lipid Res. 1985;26(4):403-17. PubMed PMID: 4009059.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of the degree of saturation of dietary fat on the hepatic production of lipoproteins in the African green monkey. AU - Johnson,F L, AU - St Clair,R W, AU - Rudel,L L, PY - 1985/4/1/pubmed PY - 1985/4/1/medline PY - 1985/4/1/entrez SP - 403 EP - 17 JF - Journal of lipid research JO - J Lipid Res VL - 26 IS - 4 N2 - The cholesteryl ester content of plasma low density lipoproteins (LDL) in monkeys has previously been shown to be related to the rate of hepatic cholesterol secretion and cholesteryl ester content of newly secreted lipoproteins in the isolated perfused liver. In the present studies, African green monkeys were fed diets containing cholesterol and 40% of calories as either butter or safflower oil in order to determine the effects of saturated versus polyunsaturated dietary fat on hepatic lipoprotein secretion. The rate of cholesterol accumulation in liver perfusates was correlated with the size of the donor's plasma LDL, but for any rate, a smaller plasma LDL was found in donor animals of the safflower oil group than in those of the butter group. Hepatic very low density lipoproteins (VLDL) were smaller in the safflower oil group but contained more cholesteryl ester and fewer triglyceride molecules per particle than those from the butter group. Livers from the safflower oil group contained more cholesteryl ester and less triglyceride than those from the butter group. The cholesteryl ester percentage composition of hepatic VLDL resembled that of the liver in each group. The data show that dietary polyunsaturated fat decreased plasma LDL size even though it increased the cholesteryl ester content of lipoproteins secreted by the liver. Therefore, intravascular formation of plasma LDL from hepatic precursor lipoproteins appears to include the removal of relatively greater amounts of cholesteryl esters from the precursor lipoproteins in polyunsaturated fat-fed animals. SN - 0022-2275 UR - https://www.unboundmedicine.com/medline/citation/4009059/Effects_of_the_degree_of_saturation_of_dietary_fat_on_the_hepatic_production_of_lipoproteins_in_the_African_green_monkey_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-2275(20)34354-6 DB - PRIME DP - Unbound Medicine ER -