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Trace element concentrations in hair from autistic children.
J Ment Defic Res 1985; 29 (Pt 1):15-22JM

Abstract

The concentrations of 14 elements were determined in scalp hair samples from control, autistic and autistic-like children. Significant differences were noted between normal males and females for calcium, magnesium and mercury. The autistic population had significantly lower levels of calcium, magnesium, copper, manganese and chromium and higher levels of lithium as compared to sex- and age-matched controls. Children with autistic features (autistic-like), classified as having childhood-onset pervasive disorder, had lower levels of magnesium, cadmium, cobalt and manganese as compared to controls. Discriminant function analysis using the 14 trace elements correctly classified 90.5% of the normal and 100% of the autistic population. Using a stepwise procedure, the five elements with the greatest discriminatory power were calcium, copper, zinc, chromium and lithium. Analysis based on these five trace elements led to the correct classification of 85.7% of the normal and 91.7% of the autistic group. Results indicate that the concentrations of trace elements in hair from normal children differ from patterns observed in both autistic and autistic-like children. Furthermore, evidence suggests that hair analysis may have potential use as a diagnostic tool for autism.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

4009700

Citation

Wecker, L, et al. "Trace Element Concentrations in Hair From Autistic Children." Journal of Mental Deficiency Research, vol. 29 (Pt 1), 1985, pp. 15-22.
Wecker L, Miller SB, Cochran SR, et al. Trace element concentrations in hair from autistic children. J Ment Defic Res. 1985;29 (Pt 1):15-22.
Wecker, L., Miller, S. B., Cochran, S. R., Dugger, D. L., & Johnson, W. D. (1985). Trace element concentrations in hair from autistic children. Journal of Mental Deficiency Research, 29 (Pt 1), pp. 15-22.
Wecker L, et al. Trace Element Concentrations in Hair From Autistic Children. J Ment Defic Res. 1985;29 (Pt 1):15-22. PubMed PMID: 4009700.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trace element concentrations in hair from autistic children. AU - Wecker,L, AU - Miller,S B, AU - Cochran,S R, AU - Dugger,D L, AU - Johnson,W D, PY - 1985/3/1/pubmed PY - 1985/3/1/medline PY - 1985/3/1/entrez SP - 15 EP - 22 JF - Journal of mental deficiency research JO - J Ment Defic Res VL - 29 (Pt 1) N2 - The concentrations of 14 elements were determined in scalp hair samples from control, autistic and autistic-like children. Significant differences were noted between normal males and females for calcium, magnesium and mercury. The autistic population had significantly lower levels of calcium, magnesium, copper, manganese and chromium and higher levels of lithium as compared to sex- and age-matched controls. Children with autistic features (autistic-like), classified as having childhood-onset pervasive disorder, had lower levels of magnesium, cadmium, cobalt and manganese as compared to controls. Discriminant function analysis using the 14 trace elements correctly classified 90.5% of the normal and 100% of the autistic population. Using a stepwise procedure, the five elements with the greatest discriminatory power were calcium, copper, zinc, chromium and lithium. Analysis based on these five trace elements led to the correct classification of 85.7% of the normal and 91.7% of the autistic group. Results indicate that the concentrations of trace elements in hair from normal children differ from patterns observed in both autistic and autistic-like children. Furthermore, evidence suggests that hair analysis may have potential use as a diagnostic tool for autism. SN - 0022-264X UR - https://www.unboundmedicine.com/medline/citation/4009700/Trace_element_concentrations_in_hair_from_autistic_children_ DB - PRIME DP - Unbound Medicine ER -