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Effects of chlorine dioxide on thyroid function in neonatal rats.
J Toxicol Environ Health. 1985; 15(2):315-22.JT

Abstract

Chlorine dioxide (ClO2), an alternative to chlorine for drinking water disinfection, has been implicated as a potential antithyroid agent (Bercz et al., 1982). Because antithyroid compounds are known to alter neurobehavioral development, the present study was designed to determine if perinatal exposure to ClO2 affects behavioral activity in rat pups. The activity cage system was designed to monitor the development of locomotor activity of a litter of pups between ages 14-21 d. Pups were exposed to ClO2 either directly, by gavaging 14 mg/kg . from age 5 to 20 d, or indirectly via their dams' drinking water in concentrations of 2, 20, or 100 mg/l from gestation to weaning (21 d postpartum). Although the activity of the indirectly exposed group was not different from controls, the gavaged group showed significantly depressed activity for d 18 and 19 postpartum. The T4 levels of the 21-d-old pups was significantly depressed in the 100-mg/l ClO2 group. The gavaged pups showed an even greater T4 depression, which correlates with their activity levels. These data support the hypothesis that ClO2 affects thyroid function and suggests that a slight depression in T4 can result in developmental delays.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

4009737

Citation

Orme, J, et al. "Effects of Chlorine Dioxide On Thyroid Function in Neonatal Rats." Journal of Toxicology and Environmental Health, vol. 15, no. 2, 1985, pp. 315-22.
Orme J, Taylor DH, Laurie RD, et al. Effects of chlorine dioxide on thyroid function in neonatal rats. J Toxicol Environ Health. 1985;15(2):315-22.
Orme, J., Taylor, D. H., Laurie, R. D., & Bull, R. J. (1985). Effects of chlorine dioxide on thyroid function in neonatal rats. Journal of Toxicology and Environmental Health, 15(2), 315-22.
Orme J, et al. Effects of Chlorine Dioxide On Thyroid Function in Neonatal Rats. J Toxicol Environ Health. 1985;15(2):315-22. PubMed PMID: 4009737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of chlorine dioxide on thyroid function in neonatal rats. AU - Orme,J, AU - Taylor,D H, AU - Laurie,R D, AU - Bull,R J, PY - 1985/1/1/pubmed PY - 1985/1/1/medline PY - 1985/1/1/entrez SP - 315 EP - 22 JF - Journal of toxicology and environmental health JO - J Toxicol Environ Health VL - 15 IS - 2 N2 - Chlorine dioxide (ClO2), an alternative to chlorine for drinking water disinfection, has been implicated as a potential antithyroid agent (Bercz et al., 1982). Because antithyroid compounds are known to alter neurobehavioral development, the present study was designed to determine if perinatal exposure to ClO2 affects behavioral activity in rat pups. The activity cage system was designed to monitor the development of locomotor activity of a litter of pups between ages 14-21 d. Pups were exposed to ClO2 either directly, by gavaging 14 mg/kg . from age 5 to 20 d, or indirectly via their dams' drinking water in concentrations of 2, 20, or 100 mg/l from gestation to weaning (21 d postpartum). Although the activity of the indirectly exposed group was not different from controls, the gavaged group showed significantly depressed activity for d 18 and 19 postpartum. The T4 levels of the 21-d-old pups was significantly depressed in the 100-mg/l ClO2 group. The gavaged pups showed an even greater T4 depression, which correlates with their activity levels. These data support the hypothesis that ClO2 affects thyroid function and suggests that a slight depression in T4 can result in developmental delays. SN - 0098-4108 UR - https://www.unboundmedicine.com/medline/citation/4009737/Effects_of_chlorine_dioxide_on_thyroid_function_in_neonatal_rats_ DB - PRIME DP - Unbound Medicine ER -