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Risk of development of gastric carcinoma in patients with pernicious anemia: a population-based study in Rochester, Minnesota.
Mayo Clin Proc 1985; 60(7):444-8MC

Abstract

To determine the long-term risk of the development of gastric cancer among patients with pernicious anemia, we identified the 152 residents of Rochester, Minnesota, who had well-documented pernicious anemia during the 30-year period 1950 through 1979. These patients were subsequently followed up for more than 1,550 person-years of observation. The observed risk of the development of a gastric cancer in this cohort was compared with that expected on the basis of incidence rates of gastric cancer for the local population. We found one case of gastric carcinoma among our 152 patients with pernicious anemia as compared with an expected incidence of 1.02 (relative risk, 1.0; 95% confidence interval, 0.02 through 5.5). We conclude that no strong indication exists for either radiographic or endoscopic surveillance in asymptomatic patients with pernicious anemia.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

4010342

Citation

Schafer, L W., et al. "Risk of Development of Gastric Carcinoma in Patients With Pernicious Anemia: a Population-based Study in Rochester, Minnesota." Mayo Clinic Proceedings, vol. 60, no. 7, 1985, pp. 444-8.
Schafer LW, Larson DE, Melton LJ, et al. Risk of development of gastric carcinoma in patients with pernicious anemia: a population-based study in Rochester, Minnesota. Mayo Clin Proc. 1985;60(7):444-8.
Schafer, L. W., Larson, D. E., Melton, L. J., Higgins, J. A., & Zinsmeister, A. R. (1985). Risk of development of gastric carcinoma in patients with pernicious anemia: a population-based study in Rochester, Minnesota. Mayo Clinic Proceedings, 60(7), pp. 444-8.
Schafer LW, et al. Risk of Development of Gastric Carcinoma in Patients With Pernicious Anemia: a Population-based Study in Rochester, Minnesota. Mayo Clin Proc. 1985;60(7):444-8. PubMed PMID: 4010342.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of development of gastric carcinoma in patients with pernicious anemia: a population-based study in Rochester, Minnesota. AU - Schafer,L W, AU - Larson,D E, AU - Melton,L J,3rd AU - Higgins,J A, AU - Zinsmeister,A R, PY - 1985/7/1/pubmed PY - 1985/7/1/medline PY - 1985/7/1/entrez SP - 444 EP - 8 JF - Mayo Clinic proceedings JO - Mayo Clin. Proc. VL - 60 IS - 7 N2 - To determine the long-term risk of the development of gastric cancer among patients with pernicious anemia, we identified the 152 residents of Rochester, Minnesota, who had well-documented pernicious anemia during the 30-year period 1950 through 1979. These patients were subsequently followed up for more than 1,550 person-years of observation. The observed risk of the development of a gastric cancer in this cohort was compared with that expected on the basis of incidence rates of gastric cancer for the local population. We found one case of gastric carcinoma among our 152 patients with pernicious anemia as compared with an expected incidence of 1.02 (relative risk, 1.0; 95% confidence interval, 0.02 through 5.5). We conclude that no strong indication exists for either radiographic or endoscopic surveillance in asymptomatic patients with pernicious anemia. SN - 0025-6196 UR - https://www.unboundmedicine.com/medline/citation/4010342/Risk_of_development_of_gastric_carcinoma_in_patients_with_pernicious_anemia:_a_population_based_study_in_Rochester_Minnesota_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0025-6196(12)60867-2 DB - PRIME DP - Unbound Medicine ER -