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Effect of peroral glycerol administration on inner ear fluid electrolytes of guinea pigs.
Ann Otol Rhinol Laryngol. 1985 May-Jun; 94(3):319-21.AO

Abstract

After the oral administration of 50% glycerol (12 mL/kg), serum, CSF and inner ear fluids from scala tympani perilymph, scala vestibuli perilymph, and scala media endolymph were collected from normal guinea pigs under sodium pentobarbital anesthesia (25-35 mg/kg). The sodium and potassium concentrations were determined by microflame photometry. Increases in sodium concentrations were found in CSF, scala tympani perilymph, scala vestibuli perilymph, and cochlear endolymph. No significant change was observed in the serum. These sodium increases were considered to be due to the dehydration caused by the osmotic action of glycerol. Potassium concentration was increased only in scala tympani perilymph. Oral administration of glycerol was found to be more gradual and effective in dehydration compared to intravenous injection.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

4014954

Citation

Kanoh, N, and K Makimoto. "Effect of Peroral Glycerol Administration On Inner Ear Fluid Electrolytes of Guinea Pigs." The Annals of Otology, Rhinology, and Laryngology, vol. 94, no. 3, 1985, pp. 319-21.
Kanoh N, Makimoto K. Effect of peroral glycerol administration on inner ear fluid electrolytes of guinea pigs. Ann Otol Rhinol Laryngol. 1985;94(3):319-21.
Kanoh, N., & Makimoto, K. (1985). Effect of peroral glycerol administration on inner ear fluid electrolytes of guinea pigs. The Annals of Otology, Rhinology, and Laryngology, 94(3), 319-21.
Kanoh N, Makimoto K. Effect of Peroral Glycerol Administration On Inner Ear Fluid Electrolytes of Guinea Pigs. Ann Otol Rhinol Laryngol. 1985 May-Jun;94(3):319-21. PubMed PMID: 4014954.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of peroral glycerol administration on inner ear fluid electrolytes of guinea pigs. AU - Kanoh,N, AU - Makimoto,K, PY - 1985/5/1/pubmed PY - 1985/5/1/medline PY - 1985/5/1/entrez SP - 319 EP - 21 JF - The Annals of otology, rhinology, and laryngology JO - Ann Otol Rhinol Laryngol VL - 94 IS - 3 N2 - After the oral administration of 50% glycerol (12 mL/kg), serum, CSF and inner ear fluids from scala tympani perilymph, scala vestibuli perilymph, and scala media endolymph were collected from normal guinea pigs under sodium pentobarbital anesthesia (25-35 mg/kg). The sodium and potassium concentrations were determined by microflame photometry. Increases in sodium concentrations were found in CSF, scala tympani perilymph, scala vestibuli perilymph, and cochlear endolymph. No significant change was observed in the serum. These sodium increases were considered to be due to the dehydration caused by the osmotic action of glycerol. Potassium concentration was increased only in scala tympani perilymph. Oral administration of glycerol was found to be more gradual and effective in dehydration compared to intravenous injection. SN - 0003-4894 UR - https://www.unboundmedicine.com/medline/citation/4014954/Effect_of_peroral_glycerol_administration_on_inner_ear_fluid_electrolytes_of_guinea_pigs_ DB - PRIME DP - Unbound Medicine ER -