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Cerebrospinal fluid Histoplasma antibodies in central nervous system histoplasmosis.
Arch Intern Med. 1985 Jul; 145(7):1237-40.AI

Abstract

We have evaluated the Histoplasma antibody response in the cerebrospinal fluid (CSF) in nine patients with central nervous system histoplasmosis and 98 controls. While the CSF Histoplasma antibody response identified eight of the nine patients, CSF cultures were positive in only two. Of controls with histoplasmosis but without meningitis (13 patients), or without histoplasmosis (85 patients), elevated CSF antibodies were detected by complement fixation in seven, by IgG radioimmunoassay in 17, and by IgM radioimmunoassay in five. Measurement of the CSF Histoplasma antibody response appears useful for identifying meningitis in patients with histoplasmosis, although cross-reactions occur in half of patients with other forms of chronic fungal meningitis. Patients with these other infections can usually be identified by tests for CSF Coccidioides antibodies, or cryptococcal antigens.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

4015272

Citation

Wheat, J, et al. "Cerebrospinal Fluid Histoplasma Antibodies in Central Nervous System Histoplasmosis." Archives of Internal Medicine, vol. 145, no. 7, 1985, pp. 1237-40.
Wheat J, French M, Batteiger B, et al. Cerebrospinal fluid Histoplasma antibodies in central nervous system histoplasmosis. Arch Intern Med. 1985;145(7):1237-40.
Wheat, J., French, M., Batteiger, B., & Kohler, R. (1985). Cerebrospinal fluid Histoplasma antibodies in central nervous system histoplasmosis. Archives of Internal Medicine, 145(7), 1237-40.
Wheat J, et al. Cerebrospinal Fluid Histoplasma Antibodies in Central Nervous System Histoplasmosis. Arch Intern Med. 1985;145(7):1237-40. PubMed PMID: 4015272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cerebrospinal fluid Histoplasma antibodies in central nervous system histoplasmosis. AU - Wheat,J, AU - French,M, AU - Batteiger,B, AU - Kohler,R, PY - 1985/7/1/pubmed PY - 1985/7/1/medline PY - 1985/7/1/entrez SP - 1237 EP - 40 JF - Archives of internal medicine JO - Arch Intern Med VL - 145 IS - 7 N2 - We have evaluated the Histoplasma antibody response in the cerebrospinal fluid (CSF) in nine patients with central nervous system histoplasmosis and 98 controls. While the CSF Histoplasma antibody response identified eight of the nine patients, CSF cultures were positive in only two. Of controls with histoplasmosis but without meningitis (13 patients), or without histoplasmosis (85 patients), elevated CSF antibodies were detected by complement fixation in seven, by IgG radioimmunoassay in 17, and by IgM radioimmunoassay in five. Measurement of the CSF Histoplasma antibody response appears useful for identifying meningitis in patients with histoplasmosis, although cross-reactions occur in half of patients with other forms of chronic fungal meningitis. Patients with these other infections can usually be identified by tests for CSF Coccidioides antibodies, or cryptococcal antigens. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/4015272/Cerebrospinal_fluid_Histoplasma_antibodies_in_central_nervous_system_histoplasmosis_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/145/pg/1237 DB - PRIME DP - Unbound Medicine ER -