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Binswanger's disease: progressive subcortical encephalopathy or multi-infarct dementia?
Can J Neurol Sci 1985; 12(2):88-94CJ

Abstract

Since Binswanger's description of subcortical arteriosclerotic encephalopathy in 1894, numerous cases have been reported. Several authors doubt the validity of this malady, although the majority consider it to be a disease entity. We report seven cases with this type of pallor of myelin, only two of which are accompanied by a history of dementia. Among the seven cases, two had arteriosclerosis of penetrating arteries and arterioles in cerebral white matter. Electron microscopy showed splitting of myelin sheaths, probably the result of edema. In reviewing the blood supply of the cerebral white matter, we conclude that no pathological alterations of medullary branches of the cerebral arteries, the same vessels supplying the white matter, can give rise to such diffuse pallor of white matter and spare the arcuate fibres. This pallor can only be due to cerebral edema, most likely of hypoxic-ischemic, hypotensive, or acidotic origin. We also contend that arteriosclerosis can only cause dementia through multiple infarcts or lacunae, if it indeed leads to dementia.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

4016596

Citation

Huang, K, et al. "Binswanger's Disease: Progressive Subcortical Encephalopathy or Multi-infarct Dementia?" The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques, vol. 12, no. 2, 1985, pp. 88-94.
Huang K, Wu L, Luo Y. Binswanger's disease: progressive subcortical encephalopathy or multi-infarct dementia? Can J Neurol Sci. 1985;12(2):88-94.
Huang, K., Wu, L., & Luo, Y. (1985). Binswanger's disease: progressive subcortical encephalopathy or multi-infarct dementia? The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques, 12(2), pp. 88-94.
Huang K, Wu L, Luo Y. Binswanger's Disease: Progressive Subcortical Encephalopathy or Multi-infarct Dementia. Can J Neurol Sci. 1985;12(2):88-94. PubMed PMID: 4016596.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Binswanger's disease: progressive subcortical encephalopathy or multi-infarct dementia? AU - Huang,K, AU - Wu,L, AU - Luo,Y, PY - 1985/5/1/pubmed PY - 1985/5/1/medline PY - 1985/5/1/entrez SP - 88 EP - 94 JF - The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques JO - Can J Neurol Sci VL - 12 IS - 2 N2 - Since Binswanger's description of subcortical arteriosclerotic encephalopathy in 1894, numerous cases have been reported. Several authors doubt the validity of this malady, although the majority consider it to be a disease entity. We report seven cases with this type of pallor of myelin, only two of which are accompanied by a history of dementia. Among the seven cases, two had arteriosclerosis of penetrating arteries and arterioles in cerebral white matter. Electron microscopy showed splitting of myelin sheaths, probably the result of edema. In reviewing the blood supply of the cerebral white matter, we conclude that no pathological alterations of medullary branches of the cerebral arteries, the same vessels supplying the white matter, can give rise to such diffuse pallor of white matter and spare the arcuate fibres. This pallor can only be due to cerebral edema, most likely of hypoxic-ischemic, hypotensive, or acidotic origin. We also contend that arteriosclerosis can only cause dementia through multiple infarcts or lacunae, if it indeed leads to dementia. SN - 0317-1671 UR - https://www.unboundmedicine.com/medline/citation/4016596/Binswanger's_disease:_progressive_subcortical_encephalopathy_or_multi_infarct_dementia L2 - http://www.diseaseinfosearch.org/result/844 DB - PRIME DP - Unbound Medicine ER -