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Value of breath hydrogen analysis in management of diarrheal illness in childhood: comparison with duodenal biopsy.
J Pediatr Gastroenterol Nutr. 1985 Jun; 4(3):381-7.JP

Abstract

Breath hydrogen tests were carried out on 157 children either because they had chronic diarrhea or because they were on disaccharide-free diets. Lactose malabsorption was common in patients with postgastroenteritis syndrome (43%), and sucrose malabsorption was readily detected in patients with congenital sucrase-isomaltase deficiency. Secondary sucrose malabsorption and small bowel bacterial overgrowth were also detected. In predicting clinical response to dietary change, the breath hydrogen test, as we perform it, was clearly the most specific and sensitive and had a predictive accuracy of 96%. Duodenal biopsy results obtained from 48 of the children gave a 23% incidence of misleading disaccharidase results (16.7% falsely normal, 6.3% falsely abnormal), but biopsy remains vital in the diagnosis of congenital sucrase-isomaltase deficiency. False negative breath hydrogen results were obtained on occasions (4%) but in most instances were related to recent antimicrobial therapy or failure of the breath test mechanics (e.g., vomiting, length of sampling).

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

4020571

Citation

Davidson, G P., and T A. Robb. "Value of Breath Hydrogen Analysis in Management of Diarrheal Illness in Childhood: Comparison With Duodenal Biopsy." Journal of Pediatric Gastroenterology and Nutrition, vol. 4, no. 3, 1985, pp. 381-7.
Davidson GP, Robb TA. Value of breath hydrogen analysis in management of diarrheal illness in childhood: comparison with duodenal biopsy. J Pediatr Gastroenterol Nutr. 1985;4(3):381-7.
Davidson, G. P., & Robb, T. A. (1985). Value of breath hydrogen analysis in management of diarrheal illness in childhood: comparison with duodenal biopsy. Journal of Pediatric Gastroenterology and Nutrition, 4(3), 381-7.
Davidson GP, Robb TA. Value of Breath Hydrogen Analysis in Management of Diarrheal Illness in Childhood: Comparison With Duodenal Biopsy. J Pediatr Gastroenterol Nutr. 1985;4(3):381-7. PubMed PMID: 4020571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Value of breath hydrogen analysis in management of diarrheal illness in childhood: comparison with duodenal biopsy. AU - Davidson,G P, AU - Robb,T A, PY - 1985/6/1/pubmed PY - 1985/6/1/medline PY - 1985/6/1/entrez SP - 381 EP - 7 JF - Journal of pediatric gastroenterology and nutrition JO - J. Pediatr. Gastroenterol. Nutr. VL - 4 IS - 3 N2 - Breath hydrogen tests were carried out on 157 children either because they had chronic diarrhea or because they were on disaccharide-free diets. Lactose malabsorption was common in patients with postgastroenteritis syndrome (43%), and sucrose malabsorption was readily detected in patients with congenital sucrase-isomaltase deficiency. Secondary sucrose malabsorption and small bowel bacterial overgrowth were also detected. In predicting clinical response to dietary change, the breath hydrogen test, as we perform it, was clearly the most specific and sensitive and had a predictive accuracy of 96%. Duodenal biopsy results obtained from 48 of the children gave a 23% incidence of misleading disaccharidase results (16.7% falsely normal, 6.3% falsely abnormal), but biopsy remains vital in the diagnosis of congenital sucrase-isomaltase deficiency. False negative breath hydrogen results were obtained on occasions (4%) but in most instances were related to recent antimicrobial therapy or failure of the breath test mechanics (e.g., vomiting, length of sampling). SN - 0277-2116 UR - https://www.unboundmedicine.com/medline/citation/4020571/Value_of_breath_hydrogen_analysis_in_management_of_diarrheal_illness_in_childhood:_comparison_with_duodenal_biopsy_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=4020571.ui DB - PRIME DP - Unbound Medicine ER -