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Response to measles vaccine in Haitian infants 6 to 12 months old. Influence of maternal antibodies, malnutrition, and concurrent illnesses.
N Engl J Med. 1985 Aug 29; 313(9):544-9.NEJM

Abstract

To study the factors affecting the serologic response to measles vaccination, we evaluated 595 Haitian infants from 6 through 12 months of age, and their mothers, at the beginning of an immunization program. Thirty-four per cent of the infants had preexisting serologic evidence of measles infections by 11 months of age. Among infants more than nine months of age, those who had had measles had a significantly lower nutritional status than those who had not (P less than 0.01). After vaccination, seroconversion rates increased from 45 per cent at 6 months to 100 per cent at 12 months. The lowest rate of vaccine failure compatible with acceptably low rates of natural infections could be achieved by vaccination after eight months of age. Infants born to mothers with low levels of antibody to measles (hemagglutination-inhibition antibody titers less than 1:40) were significantly more likely to have had natural measles (P less than 0.01) or to have seroconversion after vaccination (P less than 0.001) at 6 to 10 months of age than were infants born to mothers with higher of age than were infants born to mothers with higher titers. Malnutrition and acute infections did not affect seroconversion rates. These data support the World Health Organization recommendation to administer measles vaccine in under-developed countries as soon after nine months of age as possible, regardless of nutritional status or the presence of minor illnesses.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

4022091

Citation

Halsey, N A., et al. "Response to Measles Vaccine in Haitian Infants 6 to 12 Months Old. Influence of Maternal Antibodies, Malnutrition, and Concurrent Illnesses." The New England Journal of Medicine, vol. 313, no. 9, 1985, pp. 544-9.
Halsey NA, Boulos R, Mode F, et al. Response to measles vaccine in Haitian infants 6 to 12 months old. Influence of maternal antibodies, malnutrition, and concurrent illnesses. N Engl J Med. 1985;313(9):544-9.
Halsey, N. A., Boulos, R., Mode, F., Andre, J., Bowman, L., Yaeger, R. G., Toureau, S., Rohde, J., & Boulos, C. (1985). Response to measles vaccine in Haitian infants 6 to 12 months old. Influence of maternal antibodies, malnutrition, and concurrent illnesses. The New England Journal of Medicine, 313(9), 544-9.
Halsey NA, et al. Response to Measles Vaccine in Haitian Infants 6 to 12 Months Old. Influence of Maternal Antibodies, Malnutrition, and Concurrent Illnesses. N Engl J Med. 1985 Aug 29;313(9):544-9. PubMed PMID: 4022091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Response to measles vaccine in Haitian infants 6 to 12 months old. Influence of maternal antibodies, malnutrition, and concurrent illnesses. AU - Halsey,N A, AU - Boulos,R, AU - Mode,F, AU - Andre,J, AU - Bowman,L, AU - Yaeger,R G, AU - Toureau,S, AU - Rohde,J, AU - Boulos,C, PY - 1985/8/29/pubmed PY - 1985/8/29/medline PY - 1985/8/29/entrez SP - 544 EP - 9 JF - The New England journal of medicine JO - N Engl J Med VL - 313 IS - 9 N2 - To study the factors affecting the serologic response to measles vaccination, we evaluated 595 Haitian infants from 6 through 12 months of age, and their mothers, at the beginning of an immunization program. Thirty-four per cent of the infants had preexisting serologic evidence of measles infections by 11 months of age. Among infants more than nine months of age, those who had had measles had a significantly lower nutritional status than those who had not (P less than 0.01). After vaccination, seroconversion rates increased from 45 per cent at 6 months to 100 per cent at 12 months. The lowest rate of vaccine failure compatible with acceptably low rates of natural infections could be achieved by vaccination after eight months of age. Infants born to mothers with low levels of antibody to measles (hemagglutination-inhibition antibody titers less than 1:40) were significantly more likely to have had natural measles (P less than 0.01) or to have seroconversion after vaccination (P less than 0.001) at 6 to 10 months of age than were infants born to mothers with higher of age than were infants born to mothers with higher titers. Malnutrition and acute infections did not affect seroconversion rates. These data support the World Health Organization recommendation to administer measles vaccine in under-developed countries as soon after nine months of age as possible, regardless of nutritional status or the presence of minor illnesses. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/4022091/Response_to_measles_vaccine_in_Haitian_infants_6_to_12_months_old__Influence_of_maternal_antibodies_malnutrition_and_concurrent_illnesses_ DB - PRIME DP - Unbound Medicine ER -