Tags

Type your tag names separated by a space and hit enter

Effect of dexamethasone on prolactin and TSH responses to TRH and metoclopramide in man.
J Clin Endocrinol Metab. 1977 Feb; 44(2):237-41.JC

Abstract

We studied the effects of administration of dexamethasone, 2 mg orally every 6 h, for 5 days on the thyrotropin-releasing hormone (TRH)-induced release of prolactin (PRL), thyrotropin (TSH), triiodothyronine (T3) and thyroxine (T4) in 9 normal men and on the metoclopramide-induced release of PRL in 7 normal men. Dexamethasone suppressed the baseline serum levels of PRL, TSH and T3. The administration of dexamethasone blunted the PRL and TSH response to TRH; the blunted TSH response resulted in a decreased T3 and T4 response to TRH after dexamethasone. Following dexamethasone administration, the PRL response to metoclopramide, a dopamine antagonist which acts at the hypothalamicpituitary level to stimulate PRL secretion, was blunted in 7 normal men. The data suggest that short-term administration of pharmacological doses of glucocorticoids suppress the secretion of PRL and TSH by a direct effect on the anterior pituitary gland.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

402375

Citation

Sowers, J R., et al. "Effect of Dexamethasone On Prolactin and TSH Responses to TRH and Metoclopramide in Man." The Journal of Clinical Endocrinology and Metabolism, vol. 44, no. 2, 1977, pp. 237-41.
Sowers JR, Carlson HE, Brautbar N, et al. Effect of dexamethasone on prolactin and TSH responses to TRH and metoclopramide in man. J Clin Endocrinol Metab. 1977;44(2):237-41.
Sowers, J. R., Carlson, H. E., Brautbar, N., & Hershman, J. M. (1977). Effect of dexamethasone on prolactin and TSH responses to TRH and metoclopramide in man. The Journal of Clinical Endocrinology and Metabolism, 44(2), 237-41.
Sowers JR, et al. Effect of Dexamethasone On Prolactin and TSH Responses to TRH and Metoclopramide in Man. J Clin Endocrinol Metab. 1977;44(2):237-41. PubMed PMID: 402375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of dexamethasone on prolactin and TSH responses to TRH and metoclopramide in man. AU - Sowers,J R, AU - Carlson,H E, AU - Brautbar,N, AU - Hershman,J M, PY - 1977/2/1/pubmed PY - 1977/2/1/medline PY - 1977/2/1/entrez SP - 237 EP - 41 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 44 IS - 2 N2 - We studied the effects of administration of dexamethasone, 2 mg orally every 6 h, for 5 days on the thyrotropin-releasing hormone (TRH)-induced release of prolactin (PRL), thyrotropin (TSH), triiodothyronine (T3) and thyroxine (T4) in 9 normal men and on the metoclopramide-induced release of PRL in 7 normal men. Dexamethasone suppressed the baseline serum levels of PRL, TSH and T3. The administration of dexamethasone blunted the PRL and TSH response to TRH; the blunted TSH response resulted in a decreased T3 and T4 response to TRH after dexamethasone. Following dexamethasone administration, the PRL response to metoclopramide, a dopamine antagonist which acts at the hypothalamicpituitary level to stimulate PRL secretion, was blunted in 7 normal men. The data suggest that short-term administration of pharmacological doses of glucocorticoids suppress the secretion of PRL and TSH by a direct effect on the anterior pituitary gland. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/402375/Effect_of_dexamethasone_on_prolactin_and_TSH_responses_to_TRH_and_metoclopramide_in_man_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem-44-2-237 DB - PRIME DP - Unbound Medicine ER -