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Subclinical trace element deficiency in children with undue susceptibility to infections.

Abstract

Serum concentrations of iron, copper, zinc and magnesium and also serum transferrin and ceruloplasmin were investigated in 28 children aged 10 months to 10 years with undue susceptibility to infections. None of the children had any classical immune defect. Seven of them had had frequent upper respiratory tract infections, 16 had suffered from frequent infections of the middle ear and five from mainly lower respiratory tract infections. Thirteen healthy children aged 9 to 18 years residing in the same area served as controls. The children with undue susceptibility to infections had significantly lower mean serum iron (p less than 0.05) and zinc (p less than 0.001) levels than the healthy controls. The mean serum concentrations of copper and magnesium and of transferrin and ceruloplasmin did not differ between the patients and controls. Children with frequent middle ear infections seemed to account for most of the differences in the serum levels of iron and zinc. An inverse correlation was observed between duration of breast feeding and serum concentration of zinc, and between weight as well as height and serum magnesium. The reasons for these changes and the possible role of trace element deficiency as a factor predisposing to or perpetuating undue susceptibility to infections in children are discussed.

Authors

, ,

Source

Acta paediatrica Scandinavica 74:4 1985 Jul pg 515-20

MeSH

Ceruloplasmin
Child
Child, Preschool
Copper
Disease Susceptibility
Female
Humans
Infant
Iron
Magnesium Deficiency
Male
Otitis Media
Recurrence
Respiratory Tract Infections
Trace Elements
Transferrin
Zinc

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

4024922

Citation

Bondestam, M, et al. "Subclinical Trace Element Deficiency in Children With Undue Susceptibility to Infections." Acta Paediatrica Scandinavica, vol. 74, no. 4, 1985, pp. 515-20.
Bondestam M, Foucard T, Gebre-Medhin M. Subclinical trace element deficiency in children with undue susceptibility to infections. Acta Paediatr Scand. 1985;74(4):515-20.
Bondestam, M., Foucard, T., & Gebre-Medhin, M. (1985). Subclinical trace element deficiency in children with undue susceptibility to infections. Acta Paediatrica Scandinavica, 74(4), pp. 515-20.
Bondestam M, Foucard T, Gebre-Medhin M. Subclinical Trace Element Deficiency in Children With Undue Susceptibility to Infections. Acta Paediatr Scand. 1985;74(4):515-20. PubMed PMID: 4024922.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subclinical trace element deficiency in children with undue susceptibility to infections. AU - Bondestam,M, AU - Foucard,T, AU - Gebre-Medhin,M, PY - 1985/7/1/pubmed PY - 1985/7/1/medline PY - 1985/7/1/entrez SP - 515 EP - 20 JF - Acta paediatrica Scandinavica JO - Acta Paediatr Scand VL - 74 IS - 4 N2 - Serum concentrations of iron, copper, zinc and magnesium and also serum transferrin and ceruloplasmin were investigated in 28 children aged 10 months to 10 years with undue susceptibility to infections. None of the children had any classical immune defect. Seven of them had had frequent upper respiratory tract infections, 16 had suffered from frequent infections of the middle ear and five from mainly lower respiratory tract infections. Thirteen healthy children aged 9 to 18 years residing in the same area served as controls. The children with undue susceptibility to infections had significantly lower mean serum iron (p less than 0.05) and zinc (p less than 0.001) levels than the healthy controls. The mean serum concentrations of copper and magnesium and of transferrin and ceruloplasmin did not differ between the patients and controls. Children with frequent middle ear infections seemed to account for most of the differences in the serum levels of iron and zinc. An inverse correlation was observed between duration of breast feeding and serum concentration of zinc, and between weight as well as height and serum magnesium. The reasons for these changes and the possible role of trace element deficiency as a factor predisposing to or perpetuating undue susceptibility to infections in children are discussed. SN - 0001-656X UR - https://www.unboundmedicine.com/medline/citation/4024922/full_citation L2 - https://medlineplus.gov/earinfections.html DB - PRIME DP - Unbound Medicine ER -