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Balo's concentric sclerosis: new observations on lesion development.
Ann Neurol. 1985 Jun; 17(6):604-11.AN

Abstract

A 54-year-old woman with a four-month history of progressive neurological illness was found at postmortem examination to have lesions of Balo's concentric sclerosis. Balo lesions were found in several areas scattered widely throughout the central nervous system, including the spinal cord, a previously unreported location, and were studied by histological and ultrastructural methods. Balo lesions consisted of bands of intact myelin alternating with zones of demyelination. These lesions were centered on a perivascular cuff of inflammatory cells. The center of the lesion was the oldest area with the concentric rings of demyelination decreasing in age with increasing distance from the center. The bands of intact myelin comprised mainly remyelinated fibers, were similar to those seen at the edges of chronic active multiple sclerosis plaques, and may have represented the repaired margins of preceding episodes. The occurrence of small foci of acute demyelination centered on perivascular cuffs and other changes typical of both acute and chronic active multiple sclerosis may indicate that the lesion of Balo's concentric sclerosis represents an intermediate stage in the development of an established multiple sclerosis lesion.

Authors

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Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

4026231

Citation

Moore, G R., et al. "Balo's Concentric Sclerosis: New Observations On Lesion Development." Annals of Neurology, vol. 17, no. 6, 1985, pp. 604-11.
Moore GR, Neumann PE, Suzuki K, et al. Balo's concentric sclerosis: new observations on lesion development. Ann Neurol. 1985;17(6):604-11.
Moore, G. R., Neumann, P. E., Suzuki, K., Lijtmaer, H. N., Traugott, U., & Raine, C. S. (1985). Balo's concentric sclerosis: new observations on lesion development. Annals of Neurology, 17(6), 604-11.
Moore GR, et al. Balo's Concentric Sclerosis: New Observations On Lesion Development. Ann Neurol. 1985;17(6):604-11. PubMed PMID: 4026231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Balo's concentric sclerosis: new observations on lesion development. AU - Moore,G R, AU - Neumann,P E, AU - Suzuki,K, AU - Lijtmaer,H N, AU - Traugott,U, AU - Raine,C S, PY - 1985/6/1/pubmed PY - 1985/6/1/medline PY - 1985/6/1/entrez SP - 604 EP - 11 JF - Annals of neurology JO - Ann Neurol VL - 17 IS - 6 N2 - A 54-year-old woman with a four-month history of progressive neurological illness was found at postmortem examination to have lesions of Balo's concentric sclerosis. Balo lesions were found in several areas scattered widely throughout the central nervous system, including the spinal cord, a previously unreported location, and were studied by histological and ultrastructural methods. Balo lesions consisted of bands of intact myelin alternating with zones of demyelination. These lesions were centered on a perivascular cuff of inflammatory cells. The center of the lesion was the oldest area with the concentric rings of demyelination decreasing in age with increasing distance from the center. The bands of intact myelin comprised mainly remyelinated fibers, were similar to those seen at the edges of chronic active multiple sclerosis plaques, and may have represented the repaired margins of preceding episodes. The occurrence of small foci of acute demyelination centered on perivascular cuffs and other changes typical of both acute and chronic active multiple sclerosis may indicate that the lesion of Balo's concentric sclerosis represents an intermediate stage in the development of an established multiple sclerosis lesion. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/4026231/Balo's_concentric_sclerosis:_new_observations_on_lesion_development_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1985&volume=17&issue=6&spage=604 DB - PRIME DP - Unbound Medicine ER -