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Pseudohyponatremia in acute hyperlipemic pancreatitis. A potential pitfall in therapy.
Arch Surg. 1985 Sep; 120(9):1053-5.AS

Abstract

Six patients had apparent hyponatremia associated with hyperlipidemia and acute pancreatitis. To our knowledge, only one such patient with acute pancreatitis has previously been described, although the association of hyperlipidemia with "pseudohyponatremia" had been well documented. One of the above patients, whose condition was hemodynamically unstable on admission, developed dangerous symptoms of hyperosmolarity and cerebral dysfunction following aggressive resuscitation with hypertonic saline solution. The pseudohyponatremia results from displacement of water in the serum by the lipids, with sodium existing only in the aqueous phase. This volume displacement results in errors of sodium measurement when the latter is determined by flame photometry or indirect potentiometry, but not when determined by ultracentrifugation and direct potentiometry.

Authors

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Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

4026558

Citation

Howard, J M., and J Reed. "Pseudohyponatremia in Acute Hyperlipemic Pancreatitis. a Potential Pitfall in Therapy." Archives of Surgery (Chicago, Ill. : 1960), vol. 120, no. 9, 1985, pp. 1053-5.
Howard JM, Reed J. Pseudohyponatremia in acute hyperlipemic pancreatitis. A potential pitfall in therapy. Arch Surg. 1985;120(9):1053-5.
Howard, J. M., & Reed, J. (1985). Pseudohyponatremia in acute hyperlipemic pancreatitis. A potential pitfall in therapy. Archives of Surgery (Chicago, Ill. : 1960), 120(9), 1053-5.
Howard JM, Reed J. Pseudohyponatremia in Acute Hyperlipemic Pancreatitis. a Potential Pitfall in Therapy. Arch Surg. 1985;120(9):1053-5. PubMed PMID: 4026558.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pseudohyponatremia in acute hyperlipemic pancreatitis. A potential pitfall in therapy. AU - Howard,J M, AU - Reed,J, PY - 1985/9/1/pubmed PY - 1985/9/1/medline PY - 1985/9/1/entrez SP - 1053 EP - 5 JF - Archives of surgery (Chicago, Ill. : 1960) JO - Arch Surg VL - 120 IS - 9 N2 - Six patients had apparent hyponatremia associated with hyperlipidemia and acute pancreatitis. To our knowledge, only one such patient with acute pancreatitis has previously been described, although the association of hyperlipidemia with "pseudohyponatremia" had been well documented. One of the above patients, whose condition was hemodynamically unstable on admission, developed dangerous symptoms of hyperosmolarity and cerebral dysfunction following aggressive resuscitation with hypertonic saline solution. The pseudohyponatremia results from displacement of water in the serum by the lipids, with sodium existing only in the aqueous phase. This volume displacement results in errors of sodium measurement when the latter is determined by flame photometry or indirect potentiometry, but not when determined by ultracentrifugation and direct potentiometry. SN - 0004-0010 UR - https://www.unboundmedicine.com/medline/citation/4026558/Pseudohyponatremia_in_acute_hyperlipemic_pancreatitis__A_potential_pitfall_in_therapy_ L2 - https://jamanetwork.com/journals/jamasurgery/fullarticle/vol/120/pg/1053 DB - PRIME DP - Unbound Medicine ER -