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Allopurinol mouthwashes and 5-fluorouracil induced oral toxicity.
Eur J Surg Oncol. 1985 Sep; 11(3):267-8.EJ

Abstract

Allopurinol has been shown to decrease the gastro-intestinal and bone marrow toxicity of 5-fluorouracil. In an attempt to diminish mucositis resulting from 5-fluorouracil administration, whilst not affecting its systemic anti-tumour activity, an allopurinol mouthwash has been used. In six patients who experienced mucositis when treated initially with 5-fluorouracil, the use of an allopurinol mouthwash with subsequent courses resulted in a reduction of oral toxicity.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

4029407

Citation

Clark, P I., and M L. Slevin. "Allopurinol Mouthwashes and 5-fluorouracil Induced Oral Toxicity." European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, vol. 11, no. 3, 1985, pp. 267-8.
Clark PI, Slevin ML. Allopurinol mouthwashes and 5-fluorouracil induced oral toxicity. Eur J Surg Oncol. 1985;11(3):267-8.
Clark, P. I., & Slevin, M. L. (1985). Allopurinol mouthwashes and 5-fluorouracil induced oral toxicity. European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 11(3), 267-8.
Clark PI, Slevin ML. Allopurinol Mouthwashes and 5-fluorouracil Induced Oral Toxicity. Eur J Surg Oncol. 1985;11(3):267-8. PubMed PMID: 4029407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Allopurinol mouthwashes and 5-fluorouracil induced oral toxicity. AU - Clark,P I, AU - Slevin,M L, PY - 1985/9/1/pubmed PY - 1985/9/1/medline PY - 1985/9/1/entrez SP - 267 EP - 8 JF - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology JO - Eur J Surg Oncol VL - 11 IS - 3 N2 - Allopurinol has been shown to decrease the gastro-intestinal and bone marrow toxicity of 5-fluorouracil. In an attempt to diminish mucositis resulting from 5-fluorouracil administration, whilst not affecting its systemic anti-tumour activity, an allopurinol mouthwash has been used. In six patients who experienced mucositis when treated initially with 5-fluorouracil, the use of an allopurinol mouthwash with subsequent courses resulted in a reduction of oral toxicity. SN - 0748-7983 UR - https://www.unboundmedicine.com/medline/citation/4029407/Allopurinol_mouthwashes_and_5_fluorouracil_induced_oral_toxicity_ DB - PRIME DP - Unbound Medicine ER -