Tags

Type your tag names separated by a space and hit enter

Significance of antral pH for gastrin release by insulin hypoglycemia in duodenal ulcer patients.
Surgery. 1979 Nov; 86(5):707-13.S

Abstract

The significance of antral pH for the basal serum level of immunoreactive gastrin and for the release of gastrin during insulin hypoglycemia has been studied in duodenal ulcer (DU) patients. To permit paired comparisons, 14 DU patients underwent two or three tests with insulin. Venous blood samples were collected at fixed intervals for determination of gastrin (radioimmunoassay). In the first insulin test, the gastric juice was aspirated; in the second test, the stomach was perfused with citrate-phosphate buffer, pH 7.0; and in the third test the stomach was perfused with 0.1M HCl, pH 1.0. The rate of buffer or acid perfusion was adjusted, and the pH of the perfusate was kept above 5.0 and below 1.3, respectively. Gastric perfusion with buffer or acid for 1 hour did not affect the basal serum gastrin level, nor did perfusion with buffer for 3 hours. Insulin hypoglycemia stimulated acid secretion and produced a significant integrated serum gastrin response during gastric aspiration, but the gastrin response was four times greater during buffer perfusion. Acid perfusion abolished the gastrin response. From our previous and present findings, it is concluded that the gastrin in serum during basal conditions is of extra-antral origin and is independent of antral pH. Insulin hypoglycemia releases antral gastrin by a pH-sensitive mechanism in DU patients; the release is suppressed at pH 1.3 or less and also is markedly inhibited when the gastric juice is aspirated.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

40312

Citation

Svensson, S O., et al. "Significance of Antral pH for Gastrin Release By Insulin Hypoglycemia in Duodenal Ulcer Patients." Surgery, vol. 86, no. 5, 1979, pp. 707-13.
Svensson SO, Emås S, Kaess H, et al. Significance of antral pH for gastrin release by insulin hypoglycemia in duodenal ulcer patients. Surgery. 1979;86(5):707-13.
Svensson, S. O., Emås, S., Kaess, H., & Dörner, M. (1979). Significance of antral pH for gastrin release by insulin hypoglycemia in duodenal ulcer patients. Surgery, 86(5), 707-13.
Svensson SO, et al. Significance of Antral pH for Gastrin Release By Insulin Hypoglycemia in Duodenal Ulcer Patients. Surgery. 1979;86(5):707-13. PubMed PMID: 40312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Significance of antral pH for gastrin release by insulin hypoglycemia in duodenal ulcer patients. AU - Svensson,S O, AU - Emås,S, AU - Kaess,H, AU - Dörner,M, PY - 1979/11/1/pubmed PY - 1979/11/1/medline PY - 1979/11/1/entrez SP - 707 EP - 13 JF - Surgery JO - Surgery VL - 86 IS - 5 N2 - The significance of antral pH for the basal serum level of immunoreactive gastrin and for the release of gastrin during insulin hypoglycemia has been studied in duodenal ulcer (DU) patients. To permit paired comparisons, 14 DU patients underwent two or three tests with insulin. Venous blood samples were collected at fixed intervals for determination of gastrin (radioimmunoassay). In the first insulin test, the gastric juice was aspirated; in the second test, the stomach was perfused with citrate-phosphate buffer, pH 7.0; and in the third test the stomach was perfused with 0.1M HCl, pH 1.0. The rate of buffer or acid perfusion was adjusted, and the pH of the perfusate was kept above 5.0 and below 1.3, respectively. Gastric perfusion with buffer or acid for 1 hour did not affect the basal serum gastrin level, nor did perfusion with buffer for 3 hours. Insulin hypoglycemia stimulated acid secretion and produced a significant integrated serum gastrin response during gastric aspiration, but the gastrin response was four times greater during buffer perfusion. Acid perfusion abolished the gastrin response. From our previous and present findings, it is concluded that the gastrin in serum during basal conditions is of extra-antral origin and is independent of antral pH. Insulin hypoglycemia releases antral gastrin by a pH-sensitive mechanism in DU patients; the release is suppressed at pH 1.3 or less and also is markedly inhibited when the gastric juice is aspirated. SN - 0039-6060 UR - https://www.unboundmedicine.com/medline/citation/40312/Significance_of_antral_pH_for_gastrin_release_by_insulin_hypoglycemia_in_duodenal_ulcer_patients_ L2 - https://www.diseaseinfosearch.org/result/9680 DB - PRIME DP - Unbound Medicine ER -