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Validation of human behavioral tests using ethanol as a CNS depressant model.
Neurobehav Toxicol Teratol. 1985 May-Jun; 7(3):257-61.NT

Abstract

This study evaluated the sensitivity of a battery of tests proposed for use in determining the depressant effects of chemicals on human central nervous system (CNS) function. The first step in the development of such tests was to determine if the tests could detect the effects produced by a known CNS depressant, ethanol. Five behavioral tests, digit span memory, simple reaction time, tachistoscopic perception, flicker fusion and anticipation timing (velocity estimation) were evaluated to determine their sensitivity to the effects of ethanol at blood levels between 0.05-0.06%. Thirty-one adult male volunteers received 0 and 1.4 ml 100 proof vodka/kg body weight according to a double-blind crossover design. Tests were conducted before treatment and between 30 and 70 minutes after an ethanol or control drink was ingested. Multivariate analysis of variance (MANOVA), using composite scores representing the individual tests, indicated that the battery as a whole detected statistically significant ethanol effects. Repeated measures analysis of variance (ANOVA) comparing performance after drinking ethanol to control performance on each of the individual tests indicated a significant decrement in reaction time, tachistoscopic perception and anticipation timing.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

4033866

Citation

Baker, S J., et al. "Validation of Human Behavioral Tests Using Ethanol as a CNS Depressant Model." Neurobehavioral Toxicology and Teratology, vol. 7, no. 3, 1985, pp. 257-61.
Baker SJ, Chrzan GJ, Park CN, et al. Validation of human behavioral tests using ethanol as a CNS depressant model. Neurobehav Toxicol Teratol. 1985;7(3):257-61.
Baker, S. J., Chrzan, G. J., Park, C. N., & Saunders, J. H. (1985). Validation of human behavioral tests using ethanol as a CNS depressant model. Neurobehavioral Toxicology and Teratology, 7(3), 257-61.
Baker SJ, et al. Validation of Human Behavioral Tests Using Ethanol as a CNS Depressant Model. Neurobehav Toxicol Teratol. 1985 May-Jun;7(3):257-61. PubMed PMID: 4033866.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Validation of human behavioral tests using ethanol as a CNS depressant model. AU - Baker,S J, AU - Chrzan,G J, AU - Park,C N, AU - Saunders,J H, PY - 1985/5/1/pubmed PY - 1985/5/1/medline PY - 1985/5/1/entrez SP - 257 EP - 61 JF - Neurobehavioral toxicology and teratology JO - Neurobehav Toxicol Teratol VL - 7 IS - 3 N2 - This study evaluated the sensitivity of a battery of tests proposed for use in determining the depressant effects of chemicals on human central nervous system (CNS) function. The first step in the development of such tests was to determine if the tests could detect the effects produced by a known CNS depressant, ethanol. Five behavioral tests, digit span memory, simple reaction time, tachistoscopic perception, flicker fusion and anticipation timing (velocity estimation) were evaluated to determine their sensitivity to the effects of ethanol at blood levels between 0.05-0.06%. Thirty-one adult male volunteers received 0 and 1.4 ml 100 proof vodka/kg body weight according to a double-blind crossover design. Tests were conducted before treatment and between 30 and 70 minutes after an ethanol or control drink was ingested. Multivariate analysis of variance (MANOVA), using composite scores representing the individual tests, indicated that the battery as a whole detected statistically significant ethanol effects. Repeated measures analysis of variance (ANOVA) comparing performance after drinking ethanol to control performance on each of the individual tests indicated a significant decrement in reaction time, tachistoscopic perception and anticipation timing. SN - 0275-1380 UR - https://www.unboundmedicine.com/medline/citation/4033866/Validation_of_human_behavioral_tests_using_ethanol_as_a_CNS_depressant_model_ DB - PRIME DP - Unbound Medicine ER -