Tags

Type your tag names separated by a space and hit enter

Subcortical arteriosclerotic encephalopathy (Binswanger's disease). Computed tomographic, nuclear magnetic resonance, and clinical correlations.
Arch Neurol. 1985 Oct; 42(10):951-9.AN

Abstract

Twenty-three elderly patients were found to have a consistent pattern of leukoencephalopathy by computed tomography and nuclear magnetic resonance imaging. Eight patients presented with vague, nonspecific symptoms and had no neurologic deficits. The other 15 patients had neurologic deficits that presented in one of three ways: stroke, seven patients; slowly progressive dementia and gait disturbance, five patients; or slowly progressive dementia alone, three patients. Risk factors for arteriosclerosis (hypertension, diabetes) were present in 18 patients (78%). The necropsy of one patient revealed arteriosclerotic vasculopathy characteristic of subcortical arteriosclerotic encephalopathy (SAE) or Binswanger's disease. Subcortical arteriosclerotic encephalopathy may be a relatively common affliction of elderly patients, most of whom have risk factors for arteriosclerosis. The modes of presentation and associated clinical signs are variable, and more than one third may have no neurologic deficit. In some cases SAE overlaps with normal pressure hydrocephalus by clinical and neuroimaging criteria. Some patients with normal pressure hydrocephalus who do not respond to ventricular shunting may actually have SAE.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

4038102

Citation

Kinkel, W R., et al. "Subcortical Arteriosclerotic Encephalopathy (Binswanger's Disease). Computed Tomographic, Nuclear Magnetic Resonance, and Clinical Correlations." Archives of Neurology, vol. 42, no. 10, 1985, pp. 951-9.
Kinkel WR, Jacobs L, Polachini I, et al. Subcortical arteriosclerotic encephalopathy (Binswanger's disease). Computed tomographic, nuclear magnetic resonance, and clinical correlations. Arch Neurol. 1985;42(10):951-9.
Kinkel, W. R., Jacobs, L., Polachini, I., Bates, V., & Heffner, R. R. (1985). Subcortical arteriosclerotic encephalopathy (Binswanger's disease). Computed tomographic, nuclear magnetic resonance, and clinical correlations. Archives of Neurology, 42(10), 951-9.
Kinkel WR, et al. Subcortical Arteriosclerotic Encephalopathy (Binswanger's Disease). Computed Tomographic, Nuclear Magnetic Resonance, and Clinical Correlations. Arch Neurol. 1985;42(10):951-9. PubMed PMID: 4038102.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subcortical arteriosclerotic encephalopathy (Binswanger's disease). Computed tomographic, nuclear magnetic resonance, and clinical correlations. AU - Kinkel,W R, AU - Jacobs,L, AU - Polachini,I, AU - Bates,V, AU - Heffner,R R,Jr PY - 1985/10/1/pubmed PY - 2001/3/28/medline PY - 1985/10/1/entrez SP - 951 EP - 9 JF - Archives of neurology JO - Arch. Neurol. VL - 42 IS - 10 N2 - Twenty-three elderly patients were found to have a consistent pattern of leukoencephalopathy by computed tomography and nuclear magnetic resonance imaging. Eight patients presented with vague, nonspecific symptoms and had no neurologic deficits. The other 15 patients had neurologic deficits that presented in one of three ways: stroke, seven patients; slowly progressive dementia and gait disturbance, five patients; or slowly progressive dementia alone, three patients. Risk factors for arteriosclerosis (hypertension, diabetes) were present in 18 patients (78%). The necropsy of one patient revealed arteriosclerotic vasculopathy characteristic of subcortical arteriosclerotic encephalopathy (SAE) or Binswanger's disease. Subcortical arteriosclerotic encephalopathy may be a relatively common affliction of elderly patients, most of whom have risk factors for arteriosclerosis. The modes of presentation and associated clinical signs are variable, and more than one third may have no neurologic deficit. In some cases SAE overlaps with normal pressure hydrocephalus by clinical and neuroimaging criteria. Some patients with normal pressure hydrocephalus who do not respond to ventricular shunting may actually have SAE. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/4038102/Subcortical_arteriosclerotic_encephalopathy__Binswanger's_disease___Computed_tomographic_nuclear_magnetic_resonance_and_clinical_correlations_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/vol/42/pg/951 DB - PRIME DP - Unbound Medicine ER -