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Tests for autonomic neuropathy in diabetic children.
Aust Paediatr J. 1985 May; 21(2):105-9.AP

Abstract

Five simple tests of autonomic nerve function were studied in 38 children (12.0 years, s.d. = 3.3) with insulin-dependent diabetes mellitus and a further 38 age and sex matched controls in order to validate the use of these tests in children. The five tests included one test (immediate heart rate response to standing) previously reported. Compared to controls, diabetics showed a significantly faster heart rate at rest (P = 0.022), a reduced heart rate variation during quite respiration (P = 0.003), a smaller change in heart rate following a single deep breath (P = 0.006), a lower Valsalva ratio (P = 0.084) and a lower maximum R-R/minimum R-R ratio in response to standing (P = 0.033). The heart rate response to the Valsalva manoeuvre is less suitable for use in children than adults as it requires considerable co-ordination and co-operation and it did not correlate with the other tests of autonomic nerve function. The other tests significantly correlated with each other and were quick and easy to perform. They required no special co-operation and required no special equipment other than a standard ECG machine. Three diabetics had abnormalities in four of the tests (mean heart rate, heart rate variations during quiet respirations, change in heart rate produced by a single deep breath and the previously reported immediate heart rate response to standing). None of the controls had abnormalities in more than two of the tests.

Authors

Mitchell EA
No affiliation info available
Wealthall SR
No affiliation info available
Elliott RB
No affiliation info available

MeSH

Autonomic Nervous System DiseasesChildDiabetes Mellitus, Type 1Diabetic NeuropathiesFemaleHeart RateHumansMaleRespirationValsalva Maneuver

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

4038213

Citation

Mitchell, E A., et al. "Tests for Autonomic Neuropathy in Diabetic Children." Australian Paediatric Journal, vol. 21, no. 2, 1985, pp. 105-9.
Mitchell EA, Wealthall SR, Elliott RB. Tests for autonomic neuropathy in diabetic children. Aust Paediatr J. 1985;21(2):105-9.
Mitchell, E. A., Wealthall, S. R., & Elliott, R. B. (1985). Tests for autonomic neuropathy in diabetic children. Australian Paediatric Journal, 21(2), 105-9.
Mitchell EA, Wealthall SR, Elliott RB. Tests for Autonomic Neuropathy in Diabetic Children. Aust Paediatr J. 1985;21(2):105-9. PubMed PMID: 4038213.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tests for autonomic neuropathy in diabetic children. AU - Mitchell,E A, AU - Wealthall,S R, AU - Elliott,R B, PY - 1985/5/1/pubmed PY - 1985/5/1/medline PY - 1985/5/1/entrez SP - 105 EP - 9 JF - Australian paediatric journal JO - Aust Paediatr J VL - 21 IS - 2 N2 - Five simple tests of autonomic nerve function were studied in 38 children (12.0 years, s.d. = 3.3) with insulin-dependent diabetes mellitus and a further 38 age and sex matched controls in order to validate the use of these tests in children. The five tests included one test (immediate heart rate response to standing) previously reported. Compared to controls, diabetics showed a significantly faster heart rate at rest (P = 0.022), a reduced heart rate variation during quite respiration (P = 0.003), a smaller change in heart rate following a single deep breath (P = 0.006), a lower Valsalva ratio (P = 0.084) and a lower maximum R-R/minimum R-R ratio in response to standing (P = 0.033). The heart rate response to the Valsalva manoeuvre is less suitable for use in children than adults as it requires considerable co-ordination and co-operation and it did not correlate with the other tests of autonomic nerve function. The other tests significantly correlated with each other and were quick and easy to perform. They required no special co-operation and required no special equipment other than a standard ECG machine. Three diabetics had abnormalities in four of the tests (mean heart rate, heart rate variations during quiet respirations, change in heart rate produced by a single deep breath and the previously reported immediate heart rate response to standing). None of the controls had abnormalities in more than two of the tests. SN - 0004-993X UR - https://www.unboundmedicine.com/medline/citation/4038213/Tests_for_autonomic_neuropathy_in_diabetic_children_ DB - PRIME DP - Unbound Medicine ER -