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Unaltered aerobic power and endurance following glucocorticoid-induced muscle atrophy.
Med Sci Sports Exerc. 1985 Jun; 17(3):380-4.MS

Abstract

The present study was undertaken to evaluate whether the muscle atrophy associated with glucocorticoid excess results in a reduction in maximal oxygen uptake (VO2max) and endurance during exercise. Female rats were administered single subcutaneous injections of cortisone acetate (CA) (100 mg X kg-1 b.w.) or the vehicle (1% carboxymethyl cellulose) for 14 consecutive days. The weights of plantaris muscles (which were used as a marker of the atrophy) of CA-treated rats were 27% less than those of plantaris muscles in the vehicle-treated rats. This condition also produced a 12-fold increase in free serum glucocorticoid concentrations (cortisol) but did not alter serum androgen (testosterone) levels. Peak VO2 (ml X kg-1 X min-1) and endurance were greater in CA-treated vs vehicle-treated animals; however, these effects were shown to be a function of body weight loss. Homogenate oxygen uptakes in the presence of pyruvate or palmitate were also similar in slow-twitch soleus, fast-twitch red vastus, and fast-twitch white vastus lateralis muscles between CA- and vehicle-treated groups. These data provide no evidence to demonstrate that the catabolic actions of glucocorticoids in skeletal muscle result in a decrement in work capacity through at least 14 d of treatment.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

4040597

Citation

Capaccio, J A., et al. "Unaltered Aerobic Power and Endurance Following Glucocorticoid-induced Muscle Atrophy." Medicine and Science in Sports and Exercise, vol. 17, no. 3, 1985, pp. 380-4.
Capaccio JA, Galassi TM, Hickson RC. Unaltered aerobic power and endurance following glucocorticoid-induced muscle atrophy. Med Sci Sports Exerc. 1985;17(3):380-4.
Capaccio, J. A., Galassi, T. M., & Hickson, R. C. (1985). Unaltered aerobic power and endurance following glucocorticoid-induced muscle atrophy. Medicine and Science in Sports and Exercise, 17(3), 380-4.
Capaccio JA, Galassi TM, Hickson RC. Unaltered Aerobic Power and Endurance Following Glucocorticoid-induced Muscle Atrophy. Med Sci Sports Exerc. 1985;17(3):380-4. PubMed PMID: 4040597.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Unaltered aerobic power and endurance following glucocorticoid-induced muscle atrophy. AU - Capaccio,J A, AU - Galassi,T M, AU - Hickson,R C, PY - 1985/6/1/pubmed PY - 1985/6/1/medline PY - 1985/6/1/entrez SP - 380 EP - 4 JF - Medicine and science in sports and exercise JO - Med Sci Sports Exerc VL - 17 IS - 3 N2 - The present study was undertaken to evaluate whether the muscle atrophy associated with glucocorticoid excess results in a reduction in maximal oxygen uptake (VO2max) and endurance during exercise. Female rats were administered single subcutaneous injections of cortisone acetate (CA) (100 mg X kg-1 b.w.) or the vehicle (1% carboxymethyl cellulose) for 14 consecutive days. The weights of plantaris muscles (which were used as a marker of the atrophy) of CA-treated rats were 27% less than those of plantaris muscles in the vehicle-treated rats. This condition also produced a 12-fold increase in free serum glucocorticoid concentrations (cortisol) but did not alter serum androgen (testosterone) levels. Peak VO2 (ml X kg-1 X min-1) and endurance were greater in CA-treated vs vehicle-treated animals; however, these effects were shown to be a function of body weight loss. Homogenate oxygen uptakes in the presence of pyruvate or palmitate were also similar in slow-twitch soleus, fast-twitch red vastus, and fast-twitch white vastus lateralis muscles between CA- and vehicle-treated groups. These data provide no evidence to demonstrate that the catabolic actions of glucocorticoids in skeletal muscle result in a decrement in work capacity through at least 14 d of treatment. SN - 0195-9131 UR - https://www.unboundmedicine.com/medline/citation/4040597/Unaltered_aerobic_power_and_endurance_following_glucocorticoid_induced_muscle_atrophy_ L2 - https://Insights.ovid.com/pubmed?pmid=4040597 DB - PRIME DP - Unbound Medicine ER -