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Bacterial and polymorphonuclear leukocyte contribution to middle ear inflammation in chronic otitis media with effusion.
Ann Otol Rhinol Laryngol. 1985 Jul-Aug; 94(4 Pt 1):398-402.AO

Abstract

Bacteria can be cultured from approximately one third of chronic middle ear effusions, yet the contribution of these bacteria to the pathogenesis of chronic otitis media with effusion (OME) is not clear due to the absence of signs and symptoms of acute infection in most children with this disease. To explore the role of bacteria in chronic OME, lysozyme, lactoferrin, serum complement factors C3 and C5a, and polymorphonuclear leukocyte (PMNL) chemotaxin content was measured in 21 chronic middle ear effusion samples. Concentrations of lysozyme, lactoferrin, and chemotaxin were significantly higher in culture-positive than in sterile effusions. Lysozyme appeared to be contributed by both PMNL and non-PMNL sources in the middle ear space. These non-PMNL sources, presumably middle ear epithelial cells, accounted for 50% to 80% of the lysozyme variation in middle ear effusion. Although C3 and C5a were present in effusion, chemotaxin content correlated poorly with the C3 and C5a content, suggesting that chemotaxins were derived from bacterial peptides rather than from complement activation products. These results suggest that bacteria contribute to chronic middle ear inflammation with effusion. The eradication of bacteria from chronic middle ear effusion might disrupt the host responses which maintain chronic OME.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

4040727

Citation

Giebink, G S., et al. "Bacterial and Polymorphonuclear Leukocyte Contribution to Middle Ear Inflammation in Chronic Otitis Media With Effusion." The Annals of Otology, Rhinology, and Laryngology, vol. 94, no. 4 Pt 1, 1985, pp. 398-402.
Giebink GS, Carlson BA, Hetherington SV, et al. Bacterial and polymorphonuclear leukocyte contribution to middle ear inflammation in chronic otitis media with effusion. Ann Otol Rhinol Laryngol. 1985;94(4 Pt 1):398-402.
Giebink, G. S., Carlson, B. A., Hetherington, S. V., Hostetter, M. K., Le, C. T., & Juhn, S. K. (1985). Bacterial and polymorphonuclear leukocyte contribution to middle ear inflammation in chronic otitis media with effusion. The Annals of Otology, Rhinology, and Laryngology, 94(4 Pt 1), 398-402.
Giebink GS, et al. Bacterial and Polymorphonuclear Leukocyte Contribution to Middle Ear Inflammation in Chronic Otitis Media With Effusion. Ann Otol Rhinol Laryngol. 1985 Jul-Aug;94(4 Pt 1):398-402. PubMed PMID: 4040727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bacterial and polymorphonuclear leukocyte contribution to middle ear inflammation in chronic otitis media with effusion. AU - Giebink,G S, AU - Carlson,B A, AU - Hetherington,S V, AU - Hostetter,M K, AU - Le,C T, AU - Juhn,S K, PY - 1985/7/1/pubmed PY - 1985/7/1/medline PY - 1985/7/1/entrez SP - 398 EP - 402 JF - The Annals of otology, rhinology, and laryngology JO - Ann Otol Rhinol Laryngol VL - 94 IS - 4 Pt 1 N2 - Bacteria can be cultured from approximately one third of chronic middle ear effusions, yet the contribution of these bacteria to the pathogenesis of chronic otitis media with effusion (OME) is not clear due to the absence of signs and symptoms of acute infection in most children with this disease. To explore the role of bacteria in chronic OME, lysozyme, lactoferrin, serum complement factors C3 and C5a, and polymorphonuclear leukocyte (PMNL) chemotaxin content was measured in 21 chronic middle ear effusion samples. Concentrations of lysozyme, lactoferrin, and chemotaxin were significantly higher in culture-positive than in sterile effusions. Lysozyme appeared to be contributed by both PMNL and non-PMNL sources in the middle ear space. These non-PMNL sources, presumably middle ear epithelial cells, accounted for 50% to 80% of the lysozyme variation in middle ear effusion. Although C3 and C5a were present in effusion, chemotaxin content correlated poorly with the C3 and C5a content, suggesting that chemotaxins were derived from bacterial peptides rather than from complement activation products. These results suggest that bacteria contribute to chronic middle ear inflammation with effusion. The eradication of bacteria from chronic middle ear effusion might disrupt the host responses which maintain chronic OME. SN - 0003-4894 UR - https://www.unboundmedicine.com/medline/citation/4040727/Bacterial_and_polymorphonuclear_leukocyte_contribution_to_middle_ear_inflammation_in_chronic_otitis_media_with_effusion_ L2 - https://medlineplus.gov/earinfections.html DB - PRIME DP - Unbound Medicine ER -