Tags

Type your tag names separated by a space and hit enter

The role of allergy in the pathogenesis of otitis media with effusion.
Arch Otolaryngol. 1985 Aug; 111(8):502-6.AO

Abstract

To explain an allergic basis for the development of otitis media with effusion (OME), it was suggested that the middle ear mucosa can act as an allergic "shock organ." To evaluate this possibility, 16 juvenile rhesus monkeys were passively sensitized to pollen by intravenous injection of allergic human serum. All ears were then challenged by insufflation of pollen via the nose and eustachian tube (ET), twice daily, for four to five days. Daily tympanometry and otomicroscopy were performed, and on the last day of challenge, tympanocentesis was done to recover effusions. Five animals were killed and the middle ears were processed for histologic study. The results showed that none of the ears developed a middle ear effusion or OME. It is concluded that middle ear challenge with an appropriate pollen antigen in passively sensitized rhesus monkeys does not initiate an inflammatory reaction in the middle ear or induce OME.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

4040744

Citation

Doyle, W J., et al. "The Role of Allergy in the Pathogenesis of Otitis Media With Effusion." Archives of Otolaryngology (Chicago, Ill. : 1960), vol. 111, no. 8, 1985, pp. 502-6.
Doyle WJ, Takahara T, Fireman P. The role of allergy in the pathogenesis of otitis media with effusion. Arch Otolaryngol. 1985;111(8):502-6.
Doyle, W. J., Takahara, T., & Fireman, P. (1985). The role of allergy in the pathogenesis of otitis media with effusion. Archives of Otolaryngology (Chicago, Ill. : 1960), 111(8), 502-6.
Doyle WJ, Takahara T, Fireman P. The Role of Allergy in the Pathogenesis of Otitis Media With Effusion. Arch Otolaryngol. 1985;111(8):502-6. PubMed PMID: 4040744.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of allergy in the pathogenesis of otitis media with effusion. AU - Doyle,W J, AU - Takahara,T, AU - Fireman,P, PY - 1985/8/1/pubmed PY - 1985/8/1/medline PY - 1985/8/1/entrez SP - 502 EP - 6 JF - Archives of otolaryngology (Chicago, Ill. : 1960) JO - Arch Otolaryngol VL - 111 IS - 8 N2 - To explain an allergic basis for the development of otitis media with effusion (OME), it was suggested that the middle ear mucosa can act as an allergic "shock organ." To evaluate this possibility, 16 juvenile rhesus monkeys were passively sensitized to pollen by intravenous injection of allergic human serum. All ears were then challenged by insufflation of pollen via the nose and eustachian tube (ET), twice daily, for four to five days. Daily tympanometry and otomicroscopy were performed, and on the last day of challenge, tympanocentesis was done to recover effusions. Five animals were killed and the middle ears were processed for histologic study. The results showed that none of the ears developed a middle ear effusion or OME. It is concluded that middle ear challenge with an appropriate pollen antigen in passively sensitized rhesus monkeys does not initiate an inflammatory reaction in the middle ear or induce OME. SN - 0003-9977 UR - https://www.unboundmedicine.com/medline/citation/4040744/The_role_of_allergy_in_the_pathogenesis_of_otitis_media_with_effusion_ L2 - https://medlineplus.gov/allergy.html DB - PRIME DP - Unbound Medicine ER -