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Serum from patients with pernicious anaemia blocks gastrin stimulation of acid secretion by parietal cells.
Clin Exp Immunol. 1985 Aug; 61(2):315-22.CE

Abstract

We examined 51 sera from patients with pernicious anaemia for their capacity to block maximal gastrin stimulation of acid secretion by isolated rodent gastric parietal cells. 14C-aminopyrine accumulation was used as the index of acid secretion in vitro. Sera from patients with pernicious anaemia gave significantly (P less than 0.005) more block of maximal gastrin stimulation of acid secretion (61.7 +/- 37.8%) than sera from 10 patients with systemic lupus erythematosus (19.6 +/- 17.7%), 10 with scleroderma (34.2 +/- 22.3%), five with rheumatoid arthritis (22.4 +/- 15.6%) or 30 from healthy persons (27.4 +/- 12.8%). Maximal histamine stimulation of acid secretion was not inhibited. The blocking factor was present in serum IgG fractions, and serum and IgG fractions gave parallel dose-response and dilution curves. The serum block was abolished by absorption with gastric mucosal cells and correlated with the presence of parietal cell surface autoantibody. We conclude that serum immunoglobulin in pernicious anaemia can block gastrin stimulation of acid secretion and suggest that this block may be mediated by competition with gastrin for surface receptors on parietal cells.

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Authors

de Aizpurua HJ
No affiliation info available
Ungar B
No affiliation info available
Toh BH
No affiliation info available

MeSH

AdultAgedAminopyrineAnemia, PerniciousAnimalsArthritis, RheumatoidAutoantibodiesBinding, CompetitiveDose-Response Relationship, ImmunologicFemaleGastric AcidGastrinsHumansImmunoglobulin GIn Vitro TechniquesIntrinsic FactorLupus Erythematosus, SystemicMaleMiddle AgedParietal Cells, GastricRatsRats, Inbred StrainsScleroderma, Systemic

Pub Type(s)

Journal Article

Language

eng

PubMed ID

4042425

Citation

de Aizpurua, H J., et al. "Serum From Patients With Pernicious Anaemia Blocks Gastrin Stimulation of Acid Secretion By Parietal Cells." Clinical and Experimental Immunology, vol. 61, no. 2, 1985, pp. 315-22.
de Aizpurua HJ, Ungar B, Toh BH. Serum from patients with pernicious anaemia blocks gastrin stimulation of acid secretion by parietal cells. Clin Exp Immunol. 1985;61(2):315-22.
de Aizpurua, H. J., Ungar, B., & Toh, B. H. (1985). Serum from patients with pernicious anaemia blocks gastrin stimulation of acid secretion by parietal cells. Clinical and Experimental Immunology, 61(2), 315-22.
de Aizpurua HJ, Ungar B, Toh BH. Serum From Patients With Pernicious Anaemia Blocks Gastrin Stimulation of Acid Secretion By Parietal Cells. Clin Exp Immunol. 1985;61(2):315-22. PubMed PMID: 4042425.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum from patients with pernicious anaemia blocks gastrin stimulation of acid secretion by parietal cells. AU - de Aizpurua,H J, AU - Ungar,B, AU - Toh,B H, PY - 1985/8/1/pubmed PY - 1985/8/1/medline PY - 1985/8/1/entrez SP - 315 EP - 22 JF - Clinical and experimental immunology JO - Clin Exp Immunol VL - 61 IS - 2 N2 - We examined 51 sera from patients with pernicious anaemia for their capacity to block maximal gastrin stimulation of acid secretion by isolated rodent gastric parietal cells. 14C-aminopyrine accumulation was used as the index of acid secretion in vitro. Sera from patients with pernicious anaemia gave significantly (P less than 0.005) more block of maximal gastrin stimulation of acid secretion (61.7 +/- 37.8%) than sera from 10 patients with systemic lupus erythematosus (19.6 +/- 17.7%), 10 with scleroderma (34.2 +/- 22.3%), five with rheumatoid arthritis (22.4 +/- 15.6%) or 30 from healthy persons (27.4 +/- 12.8%). Maximal histamine stimulation of acid secretion was not inhibited. The blocking factor was present in serum IgG fractions, and serum and IgG fractions gave parallel dose-response and dilution curves. The serum block was abolished by absorption with gastric mucosal cells and correlated with the presence of parietal cell surface autoantibody. We conclude that serum immunoglobulin in pernicious anaemia can block gastrin stimulation of acid secretion and suggest that this block may be mediated by competition with gastrin for surface receptors on parietal cells. SN - 0009-9104 UR - https://www.unboundmedicine.com/medline/citation/4042425/Serum_from_patients_with_pernicious_anaemia_blocks_gastrin_stimulation_of_acid_secretion_by_parietal_cells_ DB - PRIME DP - Unbound Medicine ER -