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[Effects of piracetam during prolonged use in an experiment].
Farmakol Toksikol. 1985 Jul-Aug; 48(4):42-6.FT

Abstract

The spectrum of the pharmacological activity of piracetam administered for a long time was studied in experiments on mice and rats. It was established that administration of piracetam (300-400 mg/kg i. p.) for 10-42 days brought about potentiation of its antiamnestic effect, retardation of the processes of extinction, an increase in the emotional responsiveness, and preservation of the tranquilizing effect with no side effects (sedative or myorelaxant). The characteristic feature of piracetam effect on the extinction is its ability to decelerate this process only after its prolonged administration. It is assumed that under prolonged administration of piracetam there takes place the formation of a new functional system ensuring the memory trace stabilization.

Authors

Rakhmankulova IKh
No affiliation info available
Garibova TL
No affiliation info available
Voronin KE
No affiliation info available
Tilekeeva UM
No affiliation info available
Voronina TA
No affiliation info available

MeSH

AmnesiaAnimalsConditioning, ClassicalConflict, PsychologicalEmotionsEscape ReactionExtinction, PsychologicalLearningMaleMemoryMicePiracetamPyrrolidinonesRatsTime Factors

Pub Type(s)

Comparative Study
Journal Article

Language

rus

PubMed ID

4043362

Citation

Rakhmankulova, I Kh, et al. "[Effects of Piracetam During Prolonged Use in an Experiment]." Farmakologiia I Toksikologiia, vol. 48, no. 4, 1985, pp. 42-6.
Rakhmankulova IKh, Garibova TL, Voronin KE, et al. [Effects of piracetam during prolonged use in an experiment]. Farmakol Toksikol. 1985;48(4):42-6.
Rakhmankulova, I. K. h., Garibova, T. L., Voronin, K. E., Tilekeeva, U. M., & Voronina, T. A. (1985). [Effects of piracetam during prolonged use in an experiment]. Farmakologiia I Toksikologiia, 48(4), 42-6.
Rakhmankulova IKh, et al. [Effects of Piracetam During Prolonged Use in an Experiment]. Farmakol Toksikol. 1985 Jul-Aug;48(4):42-6. PubMed PMID: 4043362.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of piracetam during prolonged use in an experiment]. AU - Rakhmankulova,I Kh, AU - Garibova,T L, AU - Voronin,K E, AU - Tilekeeva,U M, AU - Voronina,T A, PY - 1985/7/1/pubmed PY - 1985/7/1/medline PY - 1985/7/1/entrez SP - 42 EP - 6 JF - Farmakologiia i toksikologiia JO - Farmakol Toksikol VL - 48 IS - 4 N2 - The spectrum of the pharmacological activity of piracetam administered for a long time was studied in experiments on mice and rats. It was established that administration of piracetam (300-400 mg/kg i. p.) for 10-42 days brought about potentiation of its antiamnestic effect, retardation of the processes of extinction, an increase in the emotional responsiveness, and preservation of the tranquilizing effect with no side effects (sedative or myorelaxant). The characteristic feature of piracetam effect on the extinction is its ability to decelerate this process only after its prolonged administration. It is assumed that under prolonged administration of piracetam there takes place the formation of a new functional system ensuring the memory trace stabilization. SN - 0014-8318 UR - https://www.unboundmedicine.com/medline/citation/4043362/[Effects_of_piracetam_during_prolonged_use_in_an_experiment]_ DB - PRIME DP - Unbound Medicine ER -