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Effects of ClO2 on the absorption and distribution of dietary iodide in the rat.
Fundam Appl Toxicol. 1985 Aug; 5(4):672-8.FA

Abstract

Aqueous chlorine dioxide (ClO2), an alternative disinfectant for drinking water, was found to decrease gastrointestinal (GI) bioavailability of dietary iodide. It has been previously reported that subchronic exposure to ClO2 decreases thyroxine (T4) levels in nonhuman primates. In this study in vitro experiments with animal feed, isolated rat stomachs, as well as in vivo studies with intact rats, showed that ClO2 in drinking water (at in situ concentrations as low as 2 ppm) oxidizes iodide to its reactive elemental (radical) state, binding it to organic substances present in the GI tract. A single instance of acute exposure to ClO2, however, did not decrease blood iodide levels, or thyroid glandular uptake of iodine.

Authors

Harrington RM
No affiliation info available
Shertzer HG
No affiliation info available
Bercz JP
No affiliation info available

MeSH

AnimalsChlorineChlorine CompoundsDietDose-Response Relationship, DrugIntestinal AbsorptionIodidesIodine RadioisotopesMaleOxidesRatsRats, Inbred StrainsTissue Distribution

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

4043591

Citation

Harrington, R M., et al. "Effects of ClO2 On the Absorption and Distribution of Dietary Iodide in the Rat." Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology, vol. 5, no. 4, 1985, pp. 672-8.
Harrington RM, Shertzer HG, Bercz JP. Effects of ClO2 on the absorption and distribution of dietary iodide in the rat. Fundam Appl Toxicol. 1985;5(4):672-8.
Harrington, R. M., Shertzer, H. G., & Bercz, J. P. (1985). Effects of ClO2 on the absorption and distribution of dietary iodide in the rat. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology, 5(4), 672-8.
Harrington RM, Shertzer HG, Bercz JP. Effects of ClO2 On the Absorption and Distribution of Dietary Iodide in the Rat. Fundam Appl Toxicol. 1985;5(4):672-8. PubMed PMID: 4043591.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of ClO2 on the absorption and distribution of dietary iodide in the rat. AU - Harrington,R M, AU - Shertzer,H G, AU - Bercz,J P, PY - 1985/8/1/pubmed PY - 1985/8/1/medline PY - 1985/8/1/entrez SP - 672 EP - 8 JF - Fundamental and applied toxicology : official journal of the Society of Toxicology JO - Fundam Appl Toxicol VL - 5 IS - 4 N2 - Aqueous chlorine dioxide (ClO2), an alternative disinfectant for drinking water, was found to decrease gastrointestinal (GI) bioavailability of dietary iodide. It has been previously reported that subchronic exposure to ClO2 decreases thyroxine (T4) levels in nonhuman primates. In this study in vitro experiments with animal feed, isolated rat stomachs, as well as in vivo studies with intact rats, showed that ClO2 in drinking water (at in situ concentrations as low as 2 ppm) oxidizes iodide to its reactive elemental (radical) state, binding it to organic substances present in the GI tract. A single instance of acute exposure to ClO2, however, did not decrease blood iodide levels, or thyroid glandular uptake of iodine. SN - 0272-0590 UR - https://www.unboundmedicine.com/medline/citation/4043591/Effects_of_ClO2_on_the_absorption_and_distribution_of_dietary_iodide_in_the_rat_ DB - PRIME DP - Unbound Medicine ER -