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Gliadin-specific serum immunoglobulins A, E, G, and M in childhood: relation to small intestine mucosal morphology.
J Pediatr Gastroenterol Nutr. 1985 Oct; 4(5):723-9.JP

Abstract

An enzyme-linked immunosorbent assay technique was developed to determine serum antigliadin antibodies of the IgA, IgE, IgG, and IgM classes. The antibody level of each serum specimen was expressed as an index value, i.e., optical density of test serum/optical density of cutoff, where cutoff was calculated for each immunoglobulin class as the mean + 3 SD for six healthy controls. Indices for each immunoglobulin class were determined in 69 children who were admitted for their first small intestinal mucosal biopsy due to either symptoms of malabsorption compatible with celiac disease, or short stature without other symptoms. Especially raised levels of antigliadin IgA antibodies in serum correlated strongly with villous atrophy and in infants less than or equal to 3 years of age were invariably elevated above controls, provided they were on a gluten-containing diet. Raised levels of IgG and IgE antibodies to gluten were often seen in children with normal mucosal morphology, i.e., when symptoms were due to other gastrointestinal disorders than celiac disease. It is concluded that determination of antigliadin IgA antibodies in children less than or equal to 3 years is a useful screening test before small intestinal biopsy, especially in children where the indication for biopsy is not otherwise obvious. The method can also be used to assess the results of therapy and, conceivably, compliance.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

4045630

Citation

Juto, P, et al. "Gliadin-specific Serum Immunoglobulins A, E, G, and M in Childhood: Relation to Small Intestine Mucosal Morphology." Journal of Pediatric Gastroenterology and Nutrition, vol. 4, no. 5, 1985, pp. 723-9.
Juto P, Fredrikzon B, Hernell O. Gliadin-specific serum immunoglobulins A, E, G, and M in childhood: relation to small intestine mucosal morphology. J Pediatr Gastroenterol Nutr. 1985;4(5):723-9.
Juto, P., Fredrikzon, B., & Hernell, O. (1985). Gliadin-specific serum immunoglobulins A, E, G, and M in childhood: relation to small intestine mucosal morphology. Journal of Pediatric Gastroenterology and Nutrition, 4(5), 723-9.
Juto P, Fredrikzon B, Hernell O. Gliadin-specific Serum Immunoglobulins A, E, G, and M in Childhood: Relation to Small Intestine Mucosal Morphology. J Pediatr Gastroenterol Nutr. 1985;4(5):723-9. PubMed PMID: 4045630.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gliadin-specific serum immunoglobulins A, E, G, and M in childhood: relation to small intestine mucosal morphology. AU - Juto,P, AU - Fredrikzon,B, AU - Hernell,O, PY - 1985/10/1/pubmed PY - 1985/10/1/medline PY - 1985/10/1/entrez SP - 723 EP - 9 JF - Journal of pediatric gastroenterology and nutrition JO - J Pediatr Gastroenterol Nutr VL - 4 IS - 5 N2 - An enzyme-linked immunosorbent assay technique was developed to determine serum antigliadin antibodies of the IgA, IgE, IgG, and IgM classes. The antibody level of each serum specimen was expressed as an index value, i.e., optical density of test serum/optical density of cutoff, where cutoff was calculated for each immunoglobulin class as the mean + 3 SD for six healthy controls. Indices for each immunoglobulin class were determined in 69 children who were admitted for their first small intestinal mucosal biopsy due to either symptoms of malabsorption compatible with celiac disease, or short stature without other symptoms. Especially raised levels of antigliadin IgA antibodies in serum correlated strongly with villous atrophy and in infants less than or equal to 3 years of age were invariably elevated above controls, provided they were on a gluten-containing diet. Raised levels of IgG and IgE antibodies to gluten were often seen in children with normal mucosal morphology, i.e., when symptoms were due to other gastrointestinal disorders than celiac disease. It is concluded that determination of antigliadin IgA antibodies in children less than or equal to 3 years is a useful screening test before small intestinal biopsy, especially in children where the indication for biopsy is not otherwise obvious. The method can also be used to assess the results of therapy and, conceivably, compliance. SN - 0277-2116 UR - https://www.unboundmedicine.com/medline/citation/4045630/Gliadin_specific_serum_immunoglobulins_A_E_G_and_M_in_childhood:_relation_to_small_intestine_mucosal_morphology_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=4045630.ui DB - PRIME DP - Unbound Medicine ER -