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[Pharmacokinetics and pharmacodynamics of proxyphylline in asthmatic children].
Monatsschr Kinderheilkd 1985; 133(8):520-6MK

Abstract

In 15 asthmatic children and 3 healthy adult volunteers the pharmacokinetics and pharmacodynamics of proxyphylline under oral treatment, and the pharmacokinetics after intravenous administration were determined. The concentration-time-courses after intravenous application could best be fitted to an open 2-compartment model whereas the pharmacokinetics after oral treatment followed an open 1-compartment model. Under oral administration great inter- and intraindividual variances of the serum levels occurred. These differences which showed no age-dependency were suggested to be due to variations of the absorption velocity and the elimination half-lifes. In order to evaluate the curative efficacy of proxyphylline on lung function parameters all children had to undergo a whole body-plethysmography. No significant antiobstructive effects on the relevant baseline ventilation parameters could be observed. The protective efficacy of proxyphylline was determined in asthmatic children who developed an exercise induced asthma after a 7 minutes run. Only in 3 of 11 children a significant reduction of the enhanced airway resistance occurred. No correlation between serum levels and the protective effects was found. The present results show that there is no positive association between pharmacokinetics and pharmacodynamics of proxyphylline in asthmatic children. A safe antiobstructive therapy appears to be impossible within the dose range recommended so far.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article
Randomized Controlled Trial

Language

ger

PubMed ID

4047067

Citation

Kalla, M, et al. "[Pharmacokinetics and Pharmacodynamics of Proxyphylline in Asthmatic Children]." Monatsschrift Kinderheilkunde : Organ Der Deutschen Gesellschaft Fur Kinderheilkunde, vol. 133, no. 8, 1985, pp. 520-6.
Kalla M, Richter O, Reinhardt D. [Pharmacokinetics and pharmacodynamics of proxyphylline in asthmatic children]. Monatsschr Kinderheilkd. 1985;133(8):520-6.
Kalla, M., Richter, O., & Reinhardt, D. (1985). [Pharmacokinetics and pharmacodynamics of proxyphylline in asthmatic children]. Monatsschrift Kinderheilkunde : Organ Der Deutschen Gesellschaft Fur Kinderheilkunde, 133(8), pp. 520-6.
Kalla M, Richter O, Reinhardt D. [Pharmacokinetics and Pharmacodynamics of Proxyphylline in Asthmatic Children]. Monatsschr Kinderheilkd. 1985;133(8):520-6. PubMed PMID: 4047067.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Pharmacokinetics and pharmacodynamics of proxyphylline in asthmatic children]. AU - Kalla,M, AU - Richter,O, AU - Reinhardt,D, PY - 1985/8/1/pubmed PY - 1985/8/1/medline PY - 1985/8/1/entrez SP - 520 EP - 6 JF - Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde JO - Monatsschr Kinderheilkd VL - 133 IS - 8 N2 - In 15 asthmatic children and 3 healthy adult volunteers the pharmacokinetics and pharmacodynamics of proxyphylline under oral treatment, and the pharmacokinetics after intravenous administration were determined. The concentration-time-courses after intravenous application could best be fitted to an open 2-compartment model whereas the pharmacokinetics after oral treatment followed an open 1-compartment model. Under oral administration great inter- and intraindividual variances of the serum levels occurred. These differences which showed no age-dependency were suggested to be due to variations of the absorption velocity and the elimination half-lifes. In order to evaluate the curative efficacy of proxyphylline on lung function parameters all children had to undergo a whole body-plethysmography. No significant antiobstructive effects on the relevant baseline ventilation parameters could be observed. The protective efficacy of proxyphylline was determined in asthmatic children who developed an exercise induced asthma after a 7 minutes run. Only in 3 of 11 children a significant reduction of the enhanced airway resistance occurred. No correlation between serum levels and the protective effects was found. The present results show that there is no positive association between pharmacokinetics and pharmacodynamics of proxyphylline in asthmatic children. A safe antiobstructive therapy appears to be impossible within the dose range recommended so far. SN - 0026-9298 UR - https://www.unboundmedicine.com/medline/citation/4047067/[Pharmacokinetics_and_pharmacodynamics_of_proxyphylline_in_asthmatic_children]_ L2 - https://medlineplus.gov/asthma.html DB - PRIME DP - Unbound Medicine ER -