Tags

Type your tag names separated by a space and hit enter

Management of infants with severe respiratory failure and persistence of the fetal circulation, without hyperventilation.
Pediatrics. 1985 Oct; 76(4):488-94.Ped

Abstract

The successful management of 15 infants suffering from persistence of fetal pulmonary circulation and in severe respiratory failure is presented. The treatment regimen focused on minimizing barotrauma. Infants were intubated nasotracheally and ventilated with intermittent mandatory ventilation. Peak inspiratory pressures were determined by the clinical assessment of chest excursion. Ventilator settings and fractional inspiratory oxygen (FiO2) were selected to maintain a PaO2 between 50 and 70 mm Hg; PaCO2 was not a controlling parameter and was allowed to increase as high as 60 mm Hg. Hyperventilation and muscle relaxants were not used. High ventilator rate was used in ten infants who required high inspiratory pressure to maintain chest excursion, with a favorable response in five. Tolazoline was given to 14 infants of whom ten showed an improvement in oxygenation; dopamine was given to three infants who were oliguric. All infants survived, and only one infant developed chronic lung disease which was defined by the infant's need for supplemental oxygen beyond 30 days of life.

Authors

Wung JT
No affiliation info available
James LS
No affiliation info available
Kilchevsky E
No affiliation info available
James E
No affiliation info available

MeSH

Birth WeightDopamineHumansHyperventilationInfant, NewbornIntubation, IntratrachealMeconiumPersistent Fetal Circulation SyndromePneumonia, AspirationRespiration, ArtificialRespiratory Distress Syndrome, NewbornRespiratory InsufficiencyTolazoline

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

4047792

Citation

Wung, J T., et al. "Management of Infants With Severe Respiratory Failure and Persistence of the Fetal Circulation, Without Hyperventilation." Pediatrics, vol. 76, no. 4, 1985, pp. 488-94.
Wung JT, James LS, Kilchevsky E, et al. Management of infants with severe respiratory failure and persistence of the fetal circulation, without hyperventilation. Pediatrics. 1985;76(4):488-94.
Wung, J. T., James, L. S., Kilchevsky, E., & James, E. (1985). Management of infants with severe respiratory failure and persistence of the fetal circulation, without hyperventilation. Pediatrics, 76(4), 488-94.
Wung JT, et al. Management of Infants With Severe Respiratory Failure and Persistence of the Fetal Circulation, Without Hyperventilation. Pediatrics. 1985;76(4):488-94. PubMed PMID: 4047792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Management of infants with severe respiratory failure and persistence of the fetal circulation, without hyperventilation. AU - Wung,J T, AU - James,L S, AU - Kilchevsky,E, AU - James,E, PY - 1985/10/1/pubmed PY - 1985/10/1/medline PY - 1985/10/1/entrez SP - 488 EP - 94 JF - Pediatrics JO - Pediatrics VL - 76 IS - 4 N2 - The successful management of 15 infants suffering from persistence of fetal pulmonary circulation and in severe respiratory failure is presented. The treatment regimen focused on minimizing barotrauma. Infants were intubated nasotracheally and ventilated with intermittent mandatory ventilation. Peak inspiratory pressures were determined by the clinical assessment of chest excursion. Ventilator settings and fractional inspiratory oxygen (FiO2) were selected to maintain a PaO2 between 50 and 70 mm Hg; PaCO2 was not a controlling parameter and was allowed to increase as high as 60 mm Hg. Hyperventilation and muscle relaxants were not used. High ventilator rate was used in ten infants who required high inspiratory pressure to maintain chest excursion, with a favorable response in five. Tolazoline was given to 14 infants of whom ten showed an improvement in oxygenation; dopamine was given to three infants who were oliguric. All infants survived, and only one infant developed chronic lung disease which was defined by the infant's need for supplemental oxygen beyond 30 days of life. SN - 0031-4005 UR - https://www.unboundmedicine.com/medline/citation/4047792/Management_of_infants_with_severe_respiratory_failure_and_persistence_of_the_fetal_circulation_without_hyperventilation_ DB - PRIME DP - Unbound Medicine ER -