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Phosphopyridoxal complexes with histamine and histidine. (5) The kinetics of cyclic compound formation between histamine and pyridoxal-5'-phosphate in the presence of pig kidney diamine oxidase and rat intestinal histaminase.
Agents Actions. 1977 Mar; 7(1):19-25.AA

Abstract

Pig kidney diamine oxidase (DAO) and rat intestinal histaminase (Hi-ase) activities are inhibited in vitro by high concentrations of both a substrate (histamine) and a coenzyme (pyridoxal-5'-phosphate). This inhibition may be at least partially associated with the formation of a cyclic compound between histamine (Hi) and pyridoxal-5'-phosphate (PLP). The dynamics of this cyclic compound formation in the presence of both enzymes has been examined. In an incubation mixture containing partially purified pig kidney DAO, the rate of cyclization decreased slightly as compared with a buffer. On the contrary, in the presence of crude rat intestinal histaminase, the rate of cyclization was inhibited significantly; this inhibition was proportional to the amount of enzyme preparation present in the incubation mixture. The possible mechanism of the influence of enzyme protein on the rate of cyclic compound formation, and its possible biological significance, are discussed.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

404857

Citation

Sasiak, K, et al. "Phosphopyridoxal Complexes With Histamine and Histidine. (5) the Kinetics of Cyclic Compound Formation Between Histamine and Pyridoxal-5'-phosphate in the Presence of Pig Kidney Diamine Oxidase and Rat Intestinal Histaminase." Agents and Actions, vol. 7, no. 1, 1977, pp. 19-25.
Sasiak K, Kierska D, Maśliński C. Phosphopyridoxal complexes with histamine and histidine. (5) The kinetics of cyclic compound formation between histamine and pyridoxal-5'-phosphate in the presence of pig kidney diamine oxidase and rat intestinal histaminase. Agents Actions. 1977;7(1):19-25.
Sasiak, K., Kierska, D., & Maśliński, C. (1977). Phosphopyridoxal complexes with histamine and histidine. (5) The kinetics of cyclic compound formation between histamine and pyridoxal-5'-phosphate in the presence of pig kidney diamine oxidase and rat intestinal histaminase. Agents and Actions, 7(1), 19-25.
Sasiak K, Kierska D, Maśliński C. Phosphopyridoxal Complexes With Histamine and Histidine. (5) the Kinetics of Cyclic Compound Formation Between Histamine and Pyridoxal-5'-phosphate in the Presence of Pig Kidney Diamine Oxidase and Rat Intestinal Histaminase. Agents Actions. 1977;7(1):19-25. PubMed PMID: 404857.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phosphopyridoxal complexes with histamine and histidine. (5) The kinetics of cyclic compound formation between histamine and pyridoxal-5'-phosphate in the presence of pig kidney diamine oxidase and rat intestinal histaminase. AU - Sasiak,K, AU - Kierska,D, AU - Maśliński,C, PY - 1977/3/1/pubmed PY - 1977/3/1/medline PY - 1977/3/1/entrez SP - 19 EP - 25 JF - Agents and actions JO - Agents Actions VL - 7 IS - 1 N2 - Pig kidney diamine oxidase (DAO) and rat intestinal histaminase (Hi-ase) activities are inhibited in vitro by high concentrations of both a substrate (histamine) and a coenzyme (pyridoxal-5'-phosphate). This inhibition may be at least partially associated with the formation of a cyclic compound between histamine (Hi) and pyridoxal-5'-phosphate (PLP). The dynamics of this cyclic compound formation in the presence of both enzymes has been examined. In an incubation mixture containing partially purified pig kidney DAO, the rate of cyclization decreased slightly as compared with a buffer. On the contrary, in the presence of crude rat intestinal histaminase, the rate of cyclization was inhibited significantly; this inhibition was proportional to the amount of enzyme preparation present in the incubation mixture. The possible mechanism of the influence of enzyme protein on the rate of cyclic compound formation, and its possible biological significance, are discussed. SN - 0065-4299 UR - https://www.unboundmedicine.com/medline/citation/404857/Phosphopyridoxal_complexes_with_histamine_and_histidine___5__The_kinetics_of_cyclic_compound_formation_between_histamine_and_pyridoxal_5'_phosphate_in_the_presence_of_pig_kidney_diamine_oxidase_and_rat_intestinal_histaminase_ DB - PRIME DP - Unbound Medicine ER -