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Antitumor polysaccharides from P. ostreatus (Fr.) Quél.: isolation and structure of a beta-glucan.
Carbohydr Res. 1985 Jul 01; 140(1):93-100.CR

Abstract

We isolated an antitumor glucan (HA beta-glucan) from the neutral polysaccharide fraction (A3) of a hot-water extract of the edible mushroom P. ostreatus (Fr.) Quél. Purification was accomplished by extractions with 20% sodium chloride solution saturated with thymol and by precipitations with ethanol from dimethyl sulfoxide solution. The glucan showed marked antitumor activity at a dose of 0.1 mg/kg. It is a highly branched (1----3)-beta-glucan having an average structure represented by a pentasaccharide segment consisting of one nonreducing terminal, one 3,6-di-O-substituted, and three 3-mono-O-substituted beta-D-glucopyranosyl residues. This structure was confirmed by examining 13C-n.m.r. spectra taken at 75.46 MHz.

Authors

Yoshioka Y
No affiliation info available
Tabeta R
No affiliation info available
Saitô H
No affiliation info available
Uehara N
No affiliation info available
Fukuoka F
No affiliation info available

MeSH

AnimalsAntineoplastic Agents, PhytogenicBasidiomycotaChromatography, GasConcanavalin AFemaleGas Chromatography-Mass SpectrometryMagnetic Resonance SpectroscopyMiceMice, Inbred ICRPlant LectinsPlants, MedicinalPolysaccharidesSarcoma 180

Pub Type(s)

Journal Article

Language

eng

PubMed ID

4053098

Citation

Yoshioka, Y, et al. "Antitumor Polysaccharides From P. Ostreatus (Fr.) Quél.: Isolation and Structure of a Beta-glucan." Carbohydrate Research, vol. 140, no. 1, 1985, pp. 93-100.
Yoshioka Y, Tabeta R, Saitô H, et al. Antitumor polysaccharides from P. ostreatus (Fr.) Quél.: isolation and structure of a beta-glucan. Carbohydr Res. 1985;140(1):93-100.
Yoshioka, Y., Tabeta, R., Saitô, H., Uehara, N., & Fukuoka, F. (1985). Antitumor polysaccharides from P. ostreatus (Fr.) Quél.: isolation and structure of a beta-glucan. Carbohydrate Research, 140(1), 93-100.
Yoshioka Y, et al. Antitumor Polysaccharides From P. Ostreatus (Fr.) Quél.: Isolation and Structure of a Beta-glucan. Carbohydr Res. 1985 Jul 1;140(1):93-100. PubMed PMID: 4053098.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antitumor polysaccharides from P. ostreatus (Fr.) Quél.: isolation and structure of a beta-glucan. AU - Yoshioka,Y, AU - Tabeta,R, AU - Saitô,H, AU - Uehara,N, AU - Fukuoka,F, PY - 1985/7/1/pubmed PY - 1985/7/1/medline PY - 1985/7/1/entrez SP - 93 EP - 100 JF - Carbohydrate research JO - Carbohydr Res VL - 140 IS - 1 N2 - We isolated an antitumor glucan (HA beta-glucan) from the neutral polysaccharide fraction (A3) of a hot-water extract of the edible mushroom P. ostreatus (Fr.) Quél. Purification was accomplished by extractions with 20% sodium chloride solution saturated with thymol and by precipitations with ethanol from dimethyl sulfoxide solution. The glucan showed marked antitumor activity at a dose of 0.1 mg/kg. It is a highly branched (1----3)-beta-glucan having an average structure represented by a pentasaccharide segment consisting of one nonreducing terminal, one 3,6-di-O-substituted, and three 3-mono-O-substituted beta-D-glucopyranosyl residues. This structure was confirmed by examining 13C-n.m.r. spectra taken at 75.46 MHz. SN - 0008-6215 UR - https://www.unboundmedicine.com/medline/citation/4053098/Antitumor_polysaccharides_from_P__ostreatus__Fr___Qu������l_:_isolation_and_structure_of_a_beta_glucan_ DB - PRIME DP - Unbound Medicine ER -