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Imbalance of k/lambda ratios associated with high measles antibody titers in fractionated serum immunoglobulins of patients affected with subacute sclerosing panencephalitis.
Ann Microbiol (Paris). 1977 Jan; 128A(1):89-96.AM

Abstract

Subacute sclerosing panencephalitis (SSPE) is a neurological disease which is characterized not only by the appearance of oligoclonal immunoglobulins in cerebrospinal fluid (CSF) and serum but also by high measles antibody titers and disturbed k/lambda ratios, as well in serum as in CSF. These findings lead to the hypothesis that specific immunoglobulins are produced by hyperimmunisation against measles and/or measles-like virus. Therefore the serum IgG from subacute sclerosing panencephalitis patients were fractionated by column isoelectric focusing and the k/lambda light chain ratio and the measles antibody titer of each fration were determined. The highest k/lambda ratios and the highest measles antibody titers were found mainly in two fractions at a pH ranging from 8.94-8.51 for the first and 8.88-8.24 for the second.

Authors

Bollengier F
No affiliation info available
Karcher D
No affiliation info available
Rabinovitch N
No affiliation info available

MeSH

Antibodies, ViralHumansImmunoglobulin GImmunoglobulin Light ChainsMeasles virusSubacute Sclerosing Panencephalitis

Pub Type(s)

Journal Article

Language

eng

PubMed ID

405900

Citation

Bollengier, F, et al. "Imbalance of K/lambda Ratios Associated With High Measles Antibody Titers in Fractionated Serum Immunoglobulins of Patients Affected With Subacute Sclerosing Panencephalitis." Annales De Microbiologie, vol. 128A, no. 1, 1977, pp. 89-96.
Bollengier F, Karcher D, Rabinovitch N. Imbalance of k/lambda ratios associated with high measles antibody titers in fractionated serum immunoglobulins of patients affected with subacute sclerosing panencephalitis. Ann Microbiol (Paris). 1977;128A(1):89-96.
Bollengier, F., Karcher, D., & Rabinovitch, N. (1977). Imbalance of k/lambda ratios associated with high measles antibody titers in fractionated serum immunoglobulins of patients affected with subacute sclerosing panencephalitis. Annales De Microbiologie, 128A(1), 89-96.
Bollengier F, Karcher D, Rabinovitch N. Imbalance of K/lambda Ratios Associated With High Measles Antibody Titers in Fractionated Serum Immunoglobulins of Patients Affected With Subacute Sclerosing Panencephalitis. Ann Microbiol (Paris). 1977;128A(1):89-96. PubMed PMID: 405900.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Imbalance of k/lambda ratios associated with high measles antibody titers in fractionated serum immunoglobulins of patients affected with subacute sclerosing panencephalitis. AU - Bollengier,F, AU - Karcher,D, AU - Rabinovitch,N, PY - 1977/1/1/pubmed PY - 1977/1/1/medline PY - 1977/1/1/entrez SP - 89 EP - 96 JF - Annales de microbiologie JO - Ann Microbiol (Paris) VL - 128A IS - 1 N2 - Subacute sclerosing panencephalitis (SSPE) is a neurological disease which is characterized not only by the appearance of oligoclonal immunoglobulins in cerebrospinal fluid (CSF) and serum but also by high measles antibody titers and disturbed k/lambda ratios, as well in serum as in CSF. These findings lead to the hypothesis that specific immunoglobulins are produced by hyperimmunisation against measles and/or measles-like virus. Therefore the serum IgG from subacute sclerosing panencephalitis patients were fractionated by column isoelectric focusing and the k/lambda light chain ratio and the measles antibody titer of each fration were determined. The highest k/lambda ratios and the highest measles antibody titers were found mainly in two fractions at a pH ranging from 8.94-8.51 for the first and 8.88-8.24 for the second. SN - 0300-5410 UR - https://www.unboundmedicine.com/medline/citation/405900/Imbalance_of_k/lambda_ratios_associated_with_high_measles_antibody_titers_in_fractionated_serum_immunoglobulins_of_patients_affected_with_subacute_sclerosing_panencephalitis_ L2 - https://www.diseaseinfosearch.org/result/6907 DB - PRIME DP - Unbound Medicine ER -