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Geographic mappings of colorectal cancer rates: a retrospect of studies, 1974-1984.
Cancer Detect Prev. 1985; 8(3):341-8.CD

Abstract

Geographic mapping of colorectal cancer rates revealed areas with high rates as well as areas with low rates. Comparisons between high-rate areas and areas deficient in selenium led to animal experiments that showed that selenium could reduce chemically induced intestinal tumors. A low-rate area was found to be geochemically unique with soil and water rich in potassium. This led to a series of studies indicating that elevated intracellular potassium reduces cancer risks, while elevated intracellular sodium increases the risks. Variance-reducing techniques and methods for statistical evaluation of clusters were obtained as spinoff results.

Authors

Jansson B
No affiliation info available

MeSH

Colonic NeoplasmsDietFemaleGeographyHumansMaleNational Institutes of Health (U.S.)Rectal NeoplasmsRetrospective StudiesSex FactorsUnited States

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

4064058

Citation

Jansson, B. "Geographic Mappings of Colorectal Cancer Rates: a Retrospect of Studies, 1974-1984." Cancer Detection and Prevention, vol. 8, no. 3, 1985, pp. 341-8.
Jansson B. Geographic mappings of colorectal cancer rates: a retrospect of studies, 1974-1984. Cancer Detect Prev. 1985;8(3):341-8.
Jansson, B. (1985). Geographic mappings of colorectal cancer rates: a retrospect of studies, 1974-1984. Cancer Detection and Prevention, 8(3), 341-8.
Jansson B. Geographic Mappings of Colorectal Cancer Rates: a Retrospect of Studies, 1974-1984. Cancer Detect Prev. 1985;8(3):341-8. PubMed PMID: 4064058.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Geographic mappings of colorectal cancer rates: a retrospect of studies, 1974-1984. A1 - Jansson,B, PY - 1985/1/1/pubmed PY - 1985/1/1/medline PY - 1985/1/1/entrez SP - 341 EP - 8 JF - Cancer detection and prevention JO - Cancer Detect Prev VL - 8 IS - 3 N2 - Geographic mapping of colorectal cancer rates revealed areas with high rates as well as areas with low rates. Comparisons between high-rate areas and areas deficient in selenium led to animal experiments that showed that selenium could reduce chemically induced intestinal tumors. A low-rate area was found to be geochemically unique with soil and water rich in potassium. This led to a series of studies indicating that elevated intracellular potassium reduces cancer risks, while elevated intracellular sodium increases the risks. Variance-reducing techniques and methods for statistical evaluation of clusters were obtained as spinoff results. SN - 0361-090X UR - https://www.unboundmedicine.com/medline/citation/4064058/Geographic_mappings_of_colorectal_cancer_rates:_a_retrospect_of_studies_1974_1984_ DB - PRIME DP - Unbound Medicine ER -