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Toxicity of chlorine dioxide in drinking water.
J Environ Pathol Toxicol Oncol. 1985 Sep-Oct; 6(1):105-13.JE

Abstract

Chlorine dioxide (ClO2) is currently being considered as an alternate to chlorine as a disinfectant for public water supplies. Studies were conducted to determine the toxicity of ClO2 (0, 1, 10, 100, 1000 mg/l) and its metabolites, ClO3- and ClO3- (10, 100 mg/l) in drinking water in rats. After nine months treatment the osmotic fragility of the red blood cells was decreased in all treatment groups, while a decreased blood glutathione was only observed in the metabolite groups. At 2, 4 and 6 mon no significant hematologic changes were noted in treated rats compared to control. However, after 9 mon RBC counts, hematocrit and hemoglobin were decreased in all treatment groups. ClO2, ClO2- and ClO3- administered chronically in drinking water for three months inhibited the incorporation of 3H-thymidine into nuclei of rat testes. Also, this inhibition was observed in the liver of ClO2- groups and in the kidney of 100 mg/l ClO2- treatment. The incorporation in small intestinal nuclei was increased in both 10 and 100 mg/l ClO2 and in 10 mg/l ClO2-. The treatment with Cl-compounds decreased rat body weight in all groups after 10 and 11 months treatment.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

4067828

Citation

Abdel-Rahman, M S., et al. "Toxicity of Chlorine Dioxide in Drinking Water." Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer, vol. 6, no. 1, 1985, pp. 105-13.
Abdel-Rahman MS, Couri D, Bull RJ. Toxicity of chlorine dioxide in drinking water. J Environ Pathol Toxicol Oncol. 1985;6(1):105-13.
Abdel-Rahman, M. S., Couri, D., & Bull, R. J. (1985). Toxicity of chlorine dioxide in drinking water. Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer, 6(1), 105-13.
Abdel-Rahman MS, Couri D, Bull RJ. Toxicity of Chlorine Dioxide in Drinking Water. J Environ Pathol Toxicol Oncol. 1985 Sep-Oct;6(1):105-13. PubMed PMID: 4067828.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toxicity of chlorine dioxide in drinking water. AU - Abdel-Rahman,M S, AU - Couri,D, AU - Bull,R J, PY - 1985/9/1/pubmed PY - 1985/9/1/medline PY - 1985/9/1/entrez SP - 105 EP - 13 JF - Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer JO - J Environ Pathol Toxicol Oncol VL - 6 IS - 1 N2 - Chlorine dioxide (ClO2) is currently being considered as an alternate to chlorine as a disinfectant for public water supplies. Studies were conducted to determine the toxicity of ClO2 (0, 1, 10, 100, 1000 mg/l) and its metabolites, ClO3- and ClO3- (10, 100 mg/l) in drinking water in rats. After nine months treatment the osmotic fragility of the red blood cells was decreased in all treatment groups, while a decreased blood glutathione was only observed in the metabolite groups. At 2, 4 and 6 mon no significant hematologic changes were noted in treated rats compared to control. However, after 9 mon RBC counts, hematocrit and hemoglobin were decreased in all treatment groups. ClO2, ClO2- and ClO3- administered chronically in drinking water for three months inhibited the incorporation of 3H-thymidine into nuclei of rat testes. Also, this inhibition was observed in the liver of ClO2- groups and in the kidney of 100 mg/l ClO2- treatment. The incorporation in small intestinal nuclei was increased in both 10 and 100 mg/l ClO2 and in 10 mg/l ClO2-. The treatment with Cl-compounds decreased rat body weight in all groups after 10 and 11 months treatment. SN - 0731-8898 UR - https://www.unboundmedicine.com/medline/citation/4067828/Toxicity_of_chlorine_dioxide_in_drinking_water_ DB - PRIME DP - Unbound Medicine ER -