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Ultrastructural characterization of colonic lesions in pigs inoculated with Treponema hyodysenteriae.
Can J Comp Med. 1985 Oct; 49(4):384-90.CJ

Abstract

Twelve pigs were inoculated orally with pure cultures of Treponema hyodysenteriae. Pigs were necropsied at different time intervals postinoculation; colonic specimens were collected and prepared for light and electron microscopy. The earliest colonic lesion detected by electron microscopy consisted of superficial vascular congestion and dilatation, edema of the lamina propria and intercellular separation of the epithelial cells at the crypt shoulders. This lesion progressed to epithelial cell necrosis and extrusion into the lumen and extravasation of red cells. Large numbers of spirochetes were present and free, between, over and under necrotic epithelial cells whether in place or partially extruded. Spirochetal penetration of colonic enterocytes and intracytoplasmic multiplication were confirmed in this study. The spirochetes were found to invade the epithelial cells only from their lateral borders. The relationship between T. hyodysenteriae and the colonic anaerobes was not determined.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

4075238

Citation

Albassam, M A., et al. "Ultrastructural Characterization of Colonic Lesions in Pigs Inoculated With Treponema Hyodysenteriae." Canadian Journal of Comparative Medicine : Revue Canadienne De Medecine Comparee, vol. 49, no. 4, 1985, pp. 384-90.
Albassam MA, Olander HJ, Thacker HL, et al. Ultrastructural characterization of colonic lesions in pigs inoculated with Treponema hyodysenteriae. Can J Comp Med. 1985;49(4):384-90.
Albassam, M. A., Olander, H. J., Thacker, H. L., & Turek, J. J. (1985). Ultrastructural characterization of colonic lesions in pigs inoculated with Treponema hyodysenteriae. Canadian Journal of Comparative Medicine : Revue Canadienne De Medecine Comparee, 49(4), 384-90.
Albassam MA, et al. Ultrastructural Characterization of Colonic Lesions in Pigs Inoculated With Treponema Hyodysenteriae. Can J Comp Med. 1985;49(4):384-90. PubMed PMID: 4075238.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ultrastructural characterization of colonic lesions in pigs inoculated with Treponema hyodysenteriae. AU - Albassam,M A, AU - Olander,H J, AU - Thacker,H L, AU - Turek,J J, PY - 1985/10/1/pubmed PY - 1985/10/1/medline PY - 1985/10/1/entrez SP - 384 EP - 90 JF - Canadian journal of comparative medicine : Revue canadienne de medecine comparee JO - Can. J. Comp. Med. VL - 49 IS - 4 N2 - Twelve pigs were inoculated orally with pure cultures of Treponema hyodysenteriae. Pigs were necropsied at different time intervals postinoculation; colonic specimens were collected and prepared for light and electron microscopy. The earliest colonic lesion detected by electron microscopy consisted of superficial vascular congestion and dilatation, edema of the lamina propria and intercellular separation of the epithelial cells at the crypt shoulders. This lesion progressed to epithelial cell necrosis and extrusion into the lumen and extravasation of red cells. Large numbers of spirochetes were present and free, between, over and under necrotic epithelial cells whether in place or partially extruded. Spirochetal penetration of colonic enterocytes and intracytoplasmic multiplication were confirmed in this study. The spirochetes were found to invade the epithelial cells only from their lateral borders. The relationship between T. hyodysenteriae and the colonic anaerobes was not determined. SN - 0008-4050 UR - https://www.unboundmedicine.com/medline/citation/4075238/Ultrastructural_characterization_of_colonic_lesions_in_pigs_inoculated_with_Treponema_hyodysenteriae_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/4075238/ DB - PRIME DP - Unbound Medicine ER -