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Dose-effect and dose-response relationships of blood lead to erythrocytic protoporphyrin in young children.
Environ Res. 1985 Oct; 38(1):187-96.ER

Abstract

Dose-effect and dose-response relationships were analyzed for blood lead concentration (PbB) vs blood protoporphyrin concentration using multiple data points from 165 children, ages 3-36 months. Protoporphyrin concentrations were measured using a front-face fluorometer designed to measure zinc protoporphyrin (ZPP) and an extraction method designed to measure total protoporphyrin as the free base (FEP). Estimations were made of the threshold for PbB effects on FEP and ZPP, as well as the slopes of the PbB-FEP and PbB-ZPP interactions. There was essentially no difference in thresholds estimated using ZPP vs FEP as the effect parameter. There was no apparent effect of age on threshold. However, the slope for PbB vs ZPP was less steep than the slope for PbB vs FEP. Moreover, the average ratio FEP:ZPP was markedly elevated at 3 months (1.84:1) and decreased slowly, attaining unity at 33 months. The possible reasons for this discrepancy are discussed, as well as the implications for interpretation of lead screening program data.

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Authors

Hammond PB
No affiliation info available
Bornschein RL
No affiliation info available
Succop P
No affiliation info available

MeSH

AgingAnimalsChild, PreschoolDose-Response Relationship, DrugErythrocytesHumansInfantLeadLead PoisoningPorphyrinsProtoporphyrinsRats

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

4076106

Citation

Hammond, P B., et al. "Dose-effect and Dose-response Relationships of Blood Lead to Erythrocytic Protoporphyrin in Young Children." Environmental Research, vol. 38, no. 1, 1985, pp. 187-96.
Hammond PB, Bornschein RL, Succop P. Dose-effect and dose-response relationships of blood lead to erythrocytic protoporphyrin in young children. Environ Res. 1985;38(1):187-96.
Hammond, P. B., Bornschein, R. L., & Succop, P. (1985). Dose-effect and dose-response relationships of blood lead to erythrocytic protoporphyrin in young children. Environmental Research, 38(1), 187-96.
Hammond PB, Bornschein RL, Succop P. Dose-effect and Dose-response Relationships of Blood Lead to Erythrocytic Protoporphyrin in Young Children. Environ Res. 1985;38(1):187-96. PubMed PMID: 4076106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dose-effect and dose-response relationships of blood lead to erythrocytic protoporphyrin in young children. AU - Hammond,P B, AU - Bornschein,R L, AU - Succop,P, PY - 1985/10/1/pubmed PY - 1985/10/1/medline PY - 1985/10/1/entrez SP - 187 EP - 96 JF - Environmental research JO - Environ Res VL - 38 IS - 1 N2 - Dose-effect and dose-response relationships were analyzed for blood lead concentration (PbB) vs blood protoporphyrin concentration using multiple data points from 165 children, ages 3-36 months. Protoporphyrin concentrations were measured using a front-face fluorometer designed to measure zinc protoporphyrin (ZPP) and an extraction method designed to measure total protoporphyrin as the free base (FEP). Estimations were made of the threshold for PbB effects on FEP and ZPP, as well as the slopes of the PbB-FEP and PbB-ZPP interactions. There was essentially no difference in thresholds estimated using ZPP vs FEP as the effect parameter. There was no apparent effect of age on threshold. However, the slope for PbB vs ZPP was less steep than the slope for PbB vs FEP. Moreover, the average ratio FEP:ZPP was markedly elevated at 3 months (1.84:1) and decreased slowly, attaining unity at 33 months. The possible reasons for this discrepancy are discussed, as well as the implications for interpretation of lead screening program data. SN - 0013-9351 UR - https://www.unboundmedicine.com/medline/citation/4076106/Dose_effect_and_dose_response_relationships_of_blood_lead_to_erythrocytic_protoporphyrin_in_young_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0013-9351(85)90083-0 DB - PRIME DP - Unbound Medicine ER -