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The effect of dipyridamole on histamine- and adenosine-induced bronchoconstriction in normal and asthmatic subjects.
Eur J Respir Dis. 1985 Sep; 67(3):185-92.EJ

Abstract

The effect of intravenous infusion of dipyridamole on histamine- and adenosine-induced bronchoconstriction was studied in 6 normal and 6 allergic asthmatic subjects. Dipyridamole in a single dose of 50 mg over 50 min had no effect upon baseline airway calibre measured as specific airways conductance (sGaw) and the forced expiratory volume in 1 s (FEV1). In the asthmatic subjects adenosine-induced bronchoconstriction was potentiated to a small extent by dipyridamole as indicated by a decrease in the concentration of adenosine required to produce falls from baseline of 40% for sGaw (PCs40) and 20% for FEV (PCf20) from 0.48 mg/ml to 0.32 and 0.37 mg/ml respectively. Dipyridamole had a small protective effect on histamine-induced bronchoconstriction with PCs40 and PCf20 increasing from 0.08 mg/ml to 0.11 and 0.17 mg/ml. In normal subjects dipyridamole failed to reveal a bronchoconstrictor effect of adenosine. These studies demonstrate the complex interaction between dipyridamole and bronchoconstrictor stimuli on the airways.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

4076356

Citation

Cushley, M J., et al. "The Effect of Dipyridamole On Histamine- and Adenosine-induced Bronchoconstriction in Normal and Asthmatic Subjects." European Journal of Respiratory Diseases, vol. 67, no. 3, 1985, pp. 185-92.
Cushley MJ, Tallant N, Holgate ST. The effect of dipyridamole on histamine- and adenosine-induced bronchoconstriction in normal and asthmatic subjects. Eur J Respir Dis. 1985;67(3):185-92.
Cushley, M. J., Tallant, N., & Holgate, S. T. (1985). The effect of dipyridamole on histamine- and adenosine-induced bronchoconstriction in normal and asthmatic subjects. European Journal of Respiratory Diseases, 67(3), 185-92.
Cushley MJ, Tallant N, Holgate ST. The Effect of Dipyridamole On Histamine- and Adenosine-induced Bronchoconstriction in Normal and Asthmatic Subjects. Eur J Respir Dis. 1985;67(3):185-92. PubMed PMID: 4076356.
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TY - JOUR T1 - The effect of dipyridamole on histamine- and adenosine-induced bronchoconstriction in normal and asthmatic subjects. AU - Cushley,M J, AU - Tallant,N, AU - Holgate,S T, PY - 1985/9/1/pubmed PY - 1985/9/1/medline PY - 1985/9/1/entrez SP - 185 EP - 92 JF - European journal of respiratory diseases JO - Eur J Respir Dis VL - 67 IS - 3 N2 - The effect of intravenous infusion of dipyridamole on histamine- and adenosine-induced bronchoconstriction was studied in 6 normal and 6 allergic asthmatic subjects. Dipyridamole in a single dose of 50 mg over 50 min had no effect upon baseline airway calibre measured as specific airways conductance (sGaw) and the forced expiratory volume in 1 s (FEV1). In the asthmatic subjects adenosine-induced bronchoconstriction was potentiated to a small extent by dipyridamole as indicated by a decrease in the concentration of adenosine required to produce falls from baseline of 40% for sGaw (PCs40) and 20% for FEV (PCf20) from 0.48 mg/ml to 0.32 and 0.37 mg/ml respectively. Dipyridamole had a small protective effect on histamine-induced bronchoconstriction with PCs40 and PCf20 increasing from 0.08 mg/ml to 0.11 and 0.17 mg/ml. In normal subjects dipyridamole failed to reveal a bronchoconstrictor effect of adenosine. These studies demonstrate the complex interaction between dipyridamole and bronchoconstrictor stimuli on the airways. SN - 0106-4339 UR - https://www.unboundmedicine.com/medline/citation/4076356/The_effect_of_dipyridamole_on_histamine__and_adenosine_induced_bronchoconstriction_in_normal_and_asthmatic_subjects_ L2 - https://medlineplus.gov/asthma.html DB - PRIME DP - Unbound Medicine ER -