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Immunity, transferrin, and survival in kwashiorkor.
Br Med J 1970; 4(5730):268-70BM

Abstract

In a study of 40 children with kwashiorkor, serum albumin, transferrin, and immunoglobulin levels were measured. Treatment included chloroquine, pyrimethamine, multivitamins, folic acid, iron compounds, and a high-protein diet. After two weeks the mean serum transferrin values in the children who survived and those who died were 1.30 mg./ml. and 0.33 mg./ml., respectively. Many of the children died immediately after treatment started, and it is suggested that in children with severe kwashiorkor and low serum transferrin levels any increase in free-circulating iron may result in overwhelming infection and death. Thus the appropriate time for instituting iron therapy in such patients should be reconsidered.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

4097651

Citation

Reddy, S, et al. "Immunity, Transferrin, and Survival in Kwashiorkor." British Medical Journal, vol. 4, no. 5730, 1970, pp. 268-70.
Reddy S, Adcock KJ, Adeshina H, et al. Immunity, transferrin, and survival in kwashiorkor. Br Med J. 1970;4(5730):268-70.
Reddy, S., Adcock, K. J., Adeshina, H., Cooke, A. R., Akene, J., & McFAarlane, H. (1970). Immunity, transferrin, and survival in kwashiorkor. British Medical Journal, 4(5730), pp. 268-70.
Reddy S, et al. Immunity, Transferrin, and Survival in Kwashiorkor. Br Med J. 1970 Oct 31;4(5730):268-70. PubMed PMID: 4097651.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunity, transferrin, and survival in kwashiorkor. AU - Reddy,S, AU - Adcock,K J, AU - Adeshina,H, AU - Cooke,A R, AU - Akene,J, AU - McFAarlane,H, PY - 1970/10/31/pubmed PY - 1970/10/31/medline PY - 1970/10/31/entrez SP - 268 EP - 70 JF - British medical journal JO - Br Med J VL - 4 IS - 5730 N2 - In a study of 40 children with kwashiorkor, serum albumin, transferrin, and immunoglobulin levels were measured. Treatment included chloroquine, pyrimethamine, multivitamins, folic acid, iron compounds, and a high-protein diet. After two weeks the mean serum transferrin values in the children who survived and those who died were 1.30 mg./ml. and 0.33 mg./ml., respectively. Many of the children died immediately after treatment started, and it is suggested that in children with severe kwashiorkor and low serum transferrin levels any increase in free-circulating iron may result in overwhelming infection and death. Thus the appropriate time for instituting iron therapy in such patients should be reconsidered. SN - 0007-1447 UR - https://www.unboundmedicine.com/medline/citation/4097651/Immunity_transferrin_and_survival_in_kwashiorkor_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/4097651/ DB - PRIME DP - Unbound Medicine ER -