Tags

Type your tag names separated by a space and hit enter

Modified immunofluorescence test for the serologic diagnosis of gonorrhea (FGT-ABS).
Sex Transm Dis. 1977 Apr-Jun; 4(2):44-8.ST

Abstract

Investigation of the source of false-positive reactions in the Fluorescent Gonococcal Test-Heated (FGT-H) implicated antibodies to antigens common to Neisseria gonorrhoeae and N. meningitidis. Absorption experiments proved that the fluorescence was due to both species-specific and common antigens and that in most cases the common antibodies could be successfully absorbed by a soluble protein extract of N. meningitidis. The value of such an absorption step was examined using sera from 500 women, 73 from bacteriologically confirmed cases of gonorrhea and 427 from bacteriologically and clinically negative cases. The absorption step reduced the false positivity rate by 58% without a significant change in sensitivity. The modified procedure, the Fluorescent Gonococcal Antibody Test-Absorbed (FGT-ABS), has a sensitivity similar to the Fluorescent Gonococcal Test-Heated (FGT-H) but has the advantage of higher specificity.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

410113

Citation

Gaafar, H A., and D Schoonmaker. "Modified Immunofluorescence Test for the Serologic Diagnosis of Gonorrhea (FGT-ABS)." Sexually Transmitted Diseases, vol. 4, no. 2, 1977, pp. 44-8.
Gaafar HA, Schoonmaker D. Modified immunofluorescence test for the serologic diagnosis of gonorrhea (FGT-ABS). Sex Transm Dis. 1977;4(2):44-8.
Gaafar, H. A., & Schoonmaker, D. (1977). Modified immunofluorescence test for the serologic diagnosis of gonorrhea (FGT-ABS). Sexually Transmitted Diseases, 4(2), 44-8.
Gaafar HA, Schoonmaker D. Modified Immunofluorescence Test for the Serologic Diagnosis of Gonorrhea (FGT-ABS). Sex Transm Dis. 1977 Apr-Jun;4(2):44-8. PubMed PMID: 410113.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modified immunofluorescence test for the serologic diagnosis of gonorrhea (FGT-ABS). AU - Gaafar,H A, AU - Schoonmaker,D, PY - 1977/4/1/pubmed PY - 1977/4/1/medline PY - 1977/4/1/entrez SP - 44 EP - 8 JF - Sexually transmitted diseases JO - Sex Transm Dis VL - 4 IS - 2 N2 - Investigation of the source of false-positive reactions in the Fluorescent Gonococcal Test-Heated (FGT-H) implicated antibodies to antigens common to Neisseria gonorrhoeae and N. meningitidis. Absorption experiments proved that the fluorescence was due to both species-specific and common antigens and that in most cases the common antibodies could be successfully absorbed by a soluble protein extract of N. meningitidis. The value of such an absorption step was examined using sera from 500 women, 73 from bacteriologically confirmed cases of gonorrhea and 427 from bacteriologically and clinically negative cases. The absorption step reduced the false positivity rate by 58% without a significant change in sensitivity. The modified procedure, the Fluorescent Gonococcal Antibody Test-Absorbed (FGT-ABS), has a sensitivity similar to the Fluorescent Gonococcal Test-Heated (FGT-H) but has the advantage of higher specificity. SN - 0148-5717 UR - https://www.unboundmedicine.com/medline/citation/410113/Modified_immunofluorescence_test_for_the_serologic_diagnosis_of_gonorrhea__FGT_ABS__ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=410113.ui DB - PRIME DP - Unbound Medicine ER -