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The role of the alkaline earth ions in anaphylactic histamine secretion.
J Physiol. 1972 Aug; 224(3):753-69.JP

Abstract

1. Anaphylactic histamine release from rat peritoneal mast cells is dependent on the presence of calcium ions. Graded increase of histamine release occurs as the calcium ion concentration is raised from 0.1 to 1.0 m-mole/l.2. Magnesium antagonizes the effect of calcium. The dissociation constant of the Mg-receptor complex was found to be 9.4 m-mole/l.3. Strontium will replace calcium ions in the activation of anaphylactic histamine release. Graded increase of histamine release occurs when the strontium ion concentration is raised from 1.0 to 10.0 m-mole/l.4. Magnesium also antagonizes the effect of strontium. The dissociation constant of the magnesium-receptor complex was found to be 11.0 m-mole/l.5. The log concentration-effect curve for strontium has a greater maximum and steeper slope than the curve for calcium.6. Measurements of the interaction of calcium and strontium ions are in agreement with the hypothesis that strontium possesses a higher efficacy but a lower affinity than calcium, for the ;calcium receptor' in mast cells.7. Barium will replace calcium in the activation of anaphylactic histamine release.

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Authors

Foreman JC
No affiliation info available
Mongar JL
No affiliation info available

MeSH

AnaphylaxisAnimalsAscitic FluidBariumCalciumFemaleHistamine ReleaseIn Vitro TechniquesMagnesiumMaleMast CellsOvalbuminRatsReceptors, DrugStimulation, ChemicalStrontium

Pub Type(s)

Journal Article

Language

eng

PubMed ID

4116105

Citation

Foreman, J C., and J L. Mongar. "The Role of the Alkaline Earth Ions in Anaphylactic Histamine Secretion." The Journal of Physiology, vol. 224, no. 3, 1972, pp. 753-69.
Foreman JC, Mongar JL. The role of the alkaline earth ions in anaphylactic histamine secretion. J Physiol. 1972;224(3):753-69.
Foreman, J. C., & Mongar, J. L. (1972). The role of the alkaline earth ions in anaphylactic histamine secretion. The Journal of Physiology, 224(3), 753-69.
Foreman JC, Mongar JL. The Role of the Alkaline Earth Ions in Anaphylactic Histamine Secretion. J Physiol. 1972;224(3):753-69. PubMed PMID: 4116105.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of the alkaline earth ions in anaphylactic histamine secretion. AU - Foreman,J C, AU - Mongar,J L, PY - 1972/8/1/pubmed PY - 1972/8/1/medline PY - 1972/8/1/entrez SP - 753 EP - 69 JF - The Journal of physiology JO - J Physiol VL - 224 IS - 3 N2 - 1. Anaphylactic histamine release from rat peritoneal mast cells is dependent on the presence of calcium ions. Graded increase of histamine release occurs as the calcium ion concentration is raised from 0.1 to 1.0 m-mole/l.2. Magnesium antagonizes the effect of calcium. The dissociation constant of the Mg-receptor complex was found to be 9.4 m-mole/l.3. Strontium will replace calcium ions in the activation of anaphylactic histamine release. Graded increase of histamine release occurs when the strontium ion concentration is raised from 1.0 to 10.0 m-mole/l.4. Magnesium also antagonizes the effect of strontium. The dissociation constant of the magnesium-receptor complex was found to be 11.0 m-mole/l.5. The log concentration-effect curve for strontium has a greater maximum and steeper slope than the curve for calcium.6. Measurements of the interaction of calcium and strontium ions are in agreement with the hypothesis that strontium possesses a higher efficacy but a lower affinity than calcium, for the ;calcium receptor' in mast cells.7. Barium will replace calcium in the activation of anaphylactic histamine release. SN - 0022-3751 UR - https://www.unboundmedicine.com/medline/citation/4116105/The_role_of_the_alkaline_earth_ions_in_anaphylactic_histamine_secretion_ DB - PRIME DP - Unbound Medicine ER -