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Prolactin responsiveness to TRH in amenorrheic women with and without galactorrhea.
Acta Obstet Gynecol Scand. 1977; 56(4):333-6.AO

Abstract

Sixty women were given intravenous injection of 200 microgram TRH to assess its diagnostic potential as a stimulus to PRL release. Following the administration of TRH, there was a prompt increase in serum PRL to 614.6%, to 296%, to 282.1%, and 34% in normal women, amenorrheic patients, non tumoral galactorrheic cases, and patients with pituitary tumors respectively. The TRH response above baseline of PRL levels was statistically significant in all groups, but the women with pituitary tumors which showed a blunted response. The per cent of increment of PRL levels after TRH was similar in amenorrheic women regardless the presence or not of galactorrhea; this increase was significantly greater than in patients with pituitary tumors (p less than 0.01). The per cent of increment above baseline of PRL was significantly greater in menstruating women than in amenorrheic patients (p less than 0.001). In basis of present data: 1) there is a diminished PRL secretion after TRH in amenorrheic women regardless the presence of galactorrhea or hyperprolactinemia; 2) a blunted response to TRH in hyperprolactinemic women may be indicative of a pituitary tumor.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

414510

Citation

MacGregor, C, et al. "Prolactin Responsiveness to TRH in Amenorrheic Women With and Without Galactorrhea." Acta Obstetricia Et Gynecologica Scandinavica, vol. 56, no. 4, 1977, pp. 333-6.
MacGregor C, Maldonado D, Canales ES, et al. Prolactin responsiveness to TRH in amenorrheic women with and without galactorrhea. Acta Obstet Gynecol Scand. 1977;56(4):333-6.
MacGregor, C., Maldonado, D., Canales, E. S., Soria, J., & Zárate, A. (1977). Prolactin responsiveness to TRH in amenorrheic women with and without galactorrhea. Acta Obstetricia Et Gynecologica Scandinavica, 56(4), 333-6.
MacGregor C, et al. Prolactin Responsiveness to TRH in Amenorrheic Women With and Without Galactorrhea. Acta Obstet Gynecol Scand. 1977;56(4):333-6. PubMed PMID: 414510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prolactin responsiveness to TRH in amenorrheic women with and without galactorrhea. AU - MacGregor,C, AU - Maldonado,D, AU - Canales,E S, AU - Soria,J, AU - Zárate,A, PY - 1977/1/1/pubmed PY - 1977/1/1/medline PY - 1977/1/1/entrez KW - Amenorrhea KW - Biology KW - Central Nervous System KW - Clinical Research KW - Diseases KW - Endocrine System KW - Galactorrhea KW - Hormones--administraction and dosage KW - Hormones--side effects KW - Hormones--therapeutic use KW - Human Volunteers KW - Hypothalamus KW - Menstruation Disorders KW - Physiology KW - Pituitary Gland KW - Pituitary Hormones KW - Prolactin--analysis KW - Puerperal Disorders KW - Research Methodology SP - 333 EP - 6 JF - Acta obstetricia et gynecologica Scandinavica JO - Acta Obstet Gynecol Scand VL - 56 IS - 4 N2 - Sixty women were given intravenous injection of 200 microgram TRH to assess its diagnostic potential as a stimulus to PRL release. Following the administration of TRH, there was a prompt increase in serum PRL to 614.6%, to 296%, to 282.1%, and 34% in normal women, amenorrheic patients, non tumoral galactorrheic cases, and patients with pituitary tumors respectively. The TRH response above baseline of PRL levels was statistically significant in all groups, but the women with pituitary tumors which showed a blunted response. The per cent of increment of PRL levels after TRH was similar in amenorrheic women regardless the presence or not of galactorrhea; this increase was significantly greater than in patients with pituitary tumors (p less than 0.01). The per cent of increment above baseline of PRL was significantly greater in menstruating women than in amenorrheic patients (p less than 0.001). In basis of present data: 1) there is a diminished PRL secretion after TRH in amenorrheic women regardless the presence of galactorrhea or hyperprolactinemia; 2) a blunted response to TRH in hyperprolactinemic women may be indicative of a pituitary tumor. SN - 0001-6349 UR - https://www.unboundmedicine.com/medline/citation/414510/Prolactin_responsiveness_to_TRH_in_amenorrheic_women_with_and_without_galactorrhea_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0001-6349&date=1977&volume=56&issue=4&spage=333 DB - PRIME DP - Unbound Medicine ER -