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Immunoglobulins of the middle ear fluid in acute otitis media: relationship to serum immunoglobulin concentrations and bacterial cultures.
Infect Immun. 1973 Apr; 7(4):589-93.II

Abstract

Immunoglobulin concentrations were studied in 255 specimens of middle ear fluid (MEF) from 165 episodes of acute otitis media in children. There were significant amounts of all three major immunoglobulins (Ig) in MEF, the mean concentration of IgA being 39 mg/100 ml, of IgM 63 mg/100 ml, and of IgG 383 mg/100 ml. Secretory component was present in all 10 MEF specimens in which it was sought. In patients over 9 months of age, there was a decreased likelihood of isolating pathogenic bacteria from MEF if the patient had higher concentrations of IgA in MEF than in simultaneously obtained serum. IgA concentrations were greater in MEF than in serum in almost half the patients, and the mean MEF-serum ratio for IgA was 1.38. Thus, it would appear that in this disorder MEF represents primarily a secretory response to inflammation rather than a transudate.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

4148623

Citation

Howie, V M., et al. "Immunoglobulins of the Middle Ear Fluid in Acute Otitis Media: Relationship to Serum Immunoglobulin Concentrations and Bacterial Cultures." Infection and Immunity, vol. 7, no. 4, 1973, pp. 589-93.
Howie VM, Ploussard JH, Sloyer JL, et al. Immunoglobulins of the middle ear fluid in acute otitis media: relationship to serum immunoglobulin concentrations and bacterial cultures. Infect Immun. 1973;7(4):589-93.
Howie, V. M., Ploussard, J. H., Sloyer, J. L., & Johnston, R. B. (1973). Immunoglobulins of the middle ear fluid in acute otitis media: relationship to serum immunoglobulin concentrations and bacterial cultures. Infection and Immunity, 7(4), 589-93.
Howie VM, et al. Immunoglobulins of the Middle Ear Fluid in Acute Otitis Media: Relationship to Serum Immunoglobulin Concentrations and Bacterial Cultures. Infect Immun. 1973;7(4):589-93. PubMed PMID: 4148623.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunoglobulins of the middle ear fluid in acute otitis media: relationship to serum immunoglobulin concentrations and bacterial cultures. AU - Howie,V M, AU - Ploussard,J H, AU - Sloyer,J L, AU - Johnston,R B,Jr PY - 1973/4/1/pubmed PY - 2001/3/28/medline PY - 1973/4/1/entrez SP - 589 EP - 93 JF - Infection and immunity JO - Infect Immun VL - 7 IS - 4 N2 - Immunoglobulin concentrations were studied in 255 specimens of middle ear fluid (MEF) from 165 episodes of acute otitis media in children. There were significant amounts of all three major immunoglobulins (Ig) in MEF, the mean concentration of IgA being 39 mg/100 ml, of IgM 63 mg/100 ml, and of IgG 383 mg/100 ml. Secretory component was present in all 10 MEF specimens in which it was sought. In patients over 9 months of age, there was a decreased likelihood of isolating pathogenic bacteria from MEF if the patient had higher concentrations of IgA in MEF than in simultaneously obtained serum. IgA concentrations were greater in MEF than in serum in almost half the patients, and the mean MEF-serum ratio for IgA was 1.38. Thus, it would appear that in this disorder MEF represents primarily a secretory response to inflammation rather than a transudate. SN - 0019-9567 UR - https://www.unboundmedicine.com/medline/citation/4148623/Immunoglobulins_of_the_middle_ear_fluid_in_acute_otitis_media:_relationship_to_serum_immunoglobulin_concentrations_and_bacterial_cultures_ DB - PRIME DP - Unbound Medicine ER -