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Lowering of serum 3,3',5-triiodothyronine thyroxine ratio in patients with myocardial infarction; relationship with extent of tissue injury.
Eur J Clin Invest. 1978 Apr; 8(2):99-102.EJ

Abstract

Serial measurements of haematocrit (Ht), plasma thyroxine (T4), triiodothyronine (T3) and alpha-hydroxybutyrate dehydroxygenase (alpha-HBDH) were performed in patients following myocardial infarction (MI). Infarct size was estimated by mathematical analysis of the change in plasma alpha-HBDH activity with time. After an initial small increase Ht decreased 12% until day 9 and remained constant thereafter. Serum T4 did not change during the entire study. Serum T3 decreased to 66% at day 9 and then returned to normal within 2 months. These figures are expressed relative to determinations in the first blood sample obtained within 12 h after MI. A significant correlation between the lowest serum T3/T4 ratio and infarct size was observed. These observations suggest that in these patients the peripheral conversion of T4 into T3 is reduced. This was accompanied by an increased production of reverse T3 as evidenced by observations in one patient.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

417942

Citation

Smith, S J., et al. "Lowering of Serum 3,3',5-triiodothyronine Thyroxine Ratio in Patients With Myocardial Infarction; Relationship With Extent of Tissue Injury." European Journal of Clinical Investigation, vol. 8, no. 2, 1978, pp. 99-102.
Smith SJ, Bos G, Gerbrandy J, et al. Lowering of serum 3,3',5-triiodothyronine thyroxine ratio in patients with myocardial infarction; relationship with extent of tissue injury. Eur J Clin Invest. 1978;8(2):99-102.
Smith, S. J., Bos, G., Gerbrandy, J., Docter, R., Visser, T. J., & Hennemann, G. (1978). Lowering of serum 3,3',5-triiodothyronine thyroxine ratio in patients with myocardial infarction; relationship with extent of tissue injury. European Journal of Clinical Investigation, 8(2), 99-102.
Smith SJ, et al. Lowering of Serum 3,3',5-triiodothyronine Thyroxine Ratio in Patients With Myocardial Infarction; Relationship With Extent of Tissue Injury. Eur J Clin Invest. 1978;8(2):99-102. PubMed PMID: 417942.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lowering of serum 3,3',5-triiodothyronine thyroxine ratio in patients with myocardial infarction; relationship with extent of tissue injury. AU - Smith,S J, AU - Bos,G, AU - Gerbrandy,J, AU - Docter,R, AU - Visser,T J, AU - Hennemann,G, PY - 1978/4/1/pubmed PY - 1978/4/1/medline PY - 1978/4/1/entrez SP - 99 EP - 102 JF - European journal of clinical investigation JO - Eur. J. Clin. Invest. VL - 8 IS - 2 N2 - Serial measurements of haematocrit (Ht), plasma thyroxine (T4), triiodothyronine (T3) and alpha-hydroxybutyrate dehydroxygenase (alpha-HBDH) were performed in patients following myocardial infarction (MI). Infarct size was estimated by mathematical analysis of the change in plasma alpha-HBDH activity with time. After an initial small increase Ht decreased 12% until day 9 and remained constant thereafter. Serum T4 did not change during the entire study. Serum T3 decreased to 66% at day 9 and then returned to normal within 2 months. These figures are expressed relative to determinations in the first blood sample obtained within 12 h after MI. A significant correlation between the lowest serum T3/T4 ratio and infarct size was observed. These observations suggest that in these patients the peripheral conversion of T4 into T3 is reduced. This was accompanied by an increased production of reverse T3 as evidenced by observations in one patient. SN - 0014-2972 UR - https://www.unboundmedicine.com/medline/citation/417942/Lowering_of_serum_33'5_triiodothyronine_thyroxine_ratio_in_patients_with_myocardial_infarction L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0014-2972&date=1978&volume=8&issue=2&spage=99 DB - PRIME DP - Unbound Medicine ER -